PIK3R3
Identifiers
AliasesPIK3R3, p55, p55-GAMMA, p55PIK, phosphoinositide-3-kinase regulatory subunit 3, PI3KR3
External IDsOMIM: 606076 MGI: 109277 HomoloGene: 2690 GeneCards: PIK3R3
Orthologs
SpeciesHumanMouse
Entrez

8503

18710

Ensembl

ENSG00000117461

ENSMUSG00000028698

UniProt

Q92569

Q64143

RefSeq (mRNA)

NM_181585
NM_001355584
NM_001355585
NM_001355586

RefSeq (protein)

NP_853616
NP_001342513
NP_001342514
NP_001342515

Location (UCSC)Chr 1: 46.04 – 46.13 MbChr 4: 116.08 – 116.16 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Phosphatidylinositol 3-kinase regulatory subunit gamma is an enzyme, which in humans is encoded by the PIK3R3 gene.[5][6]


Interactions

PIK3R3 has been shown to interact with Insulin-like growth factor 1 receptor,[7] IRS1[7][8] and Retinoblastoma protein.[9]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000117461 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028698 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Dey BR, Furlanetto RW, Nissley SP (May 1998). "Cloning of human p55 gamma, a regulatory subunit of phosphatidylinositol 3-kinase, by a yeast two-hybrid library screen with the insulin-like growth factor-I receptor". Gene. 209 (1–2): 175–83. doi:10.1016/S0378-1119(98)00045-6. PMID 9524259.
  6. ^ "Entrez Gene: PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (p55, gamma)".
  7. ^ a b Mothe, I; Delahaye L; Filloux C; Pons S; White M F; Van Obberghen E (Dec 1997). "Interaction of wild type and dominant-negative p55PIK regulatory subunit of phosphatidylinositol 3-kinase with insulin-like growth factor-1 signaling proteins". Mol. Endocrinol. 11 (13): 1911–23. doi:10.1210/mend.11.13.0029. ISSN 0888-8809. PMID 9415396.
  8. ^ Xia, X; Serrero G (Aug 1999). "Multiple forms of p55PIK, a regulatory subunit of phosphoinositide 3-kinase, are generated by alternative initiation of translation". Biochem. J. 341 (3): 831–7. doi:10.1042/0264-6021:3410831. ISSN 0264-6021. PMC 1220424. PMID 10417350.
  9. ^ Xia, Xianmin; Cheng Aiwu; Akinmade Damilola; Hamburger Anne W (Mar 2003). "The N-Terminal 24 Amino Acids of the p55 Gamma Regulatory Subunit of Phosphoinositide 3-Kinase Binds Rb and Induces Cell Cycle Arrest". Mol. Cell. Biol. 23 (5): 1717–25. doi:10.1128/MCB.23.5.1717-1725.2003. ISSN 0270-7306. PMC 151709. PMID 12588990.

Further reading


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