Protein-coding gene in the species Homo sapiens
PPIP5K2 Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3T54 , 3T7A , 3T99 , 3T9A , 3T9B , 3T9C , 3T9D , 3T9E , 3T9F , 4HN2 , 4NZM , 4NZN , 4NZO , 4Q4C , 4Q4D , 5BYA , 5BYB
Identifiers Aliases PPIP5K2 , HISPPD1, IP7K2, VIP2, CFAP160, diphosphoinositol pentakisphosphate kinase 2, DFNB100External IDs OMIM : 611648 ; MGI : 2142810 ; HomoloGene : 49409 ; GeneCards : PPIP5K2 ; OMA :PPIP5K2 - orthologs Wikidata
Diphosphoinositol pentakisphosphate kinase 2 is a protein that in humans is encoded by the PPIP5K2 gene .
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Function
Inositol phosphates (IPs) and diphosphoinositol phosphates (PP-IPs), also known as inositol pyrophosphates, act as cell signaling molecules.
HISPPD1 has both IP6 kinase (EC 2.7.4.21) and PP-IP5 (also called IP7) kinase (EC 2.7.4.24) activities that produce the high-energy pyrophosphates PP-IP5 and PP2-IP4 (also called IP8), respectively (Fridy et al., 2007 [PubMed 17690096]).
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Wang H, Falck JR , Hall TM, Shears SB (2011). "Structural basis for an inositol pyrophosphate kinase surmounting phosphate crowding" . Nat. Chem. Biol . 8 (1): 111–6. doi :10.1038/nchembio.733 . PMC 3923263 . PMID 22119861 .
Weaver JD, Wang H, Shears SB (2013). "The kinetic properties of a human PPIP5K reveal that its kinase activities are protected against the consequences of a deteriorating cellular bioenergetic environment" . Biosci. Rep . 33 (2): e00022. doi :10.1042/BSR20120115 . PMC 3564036 . PMID 23240582 .
Yong ST, Nguyen HN, Choi JH, Bortner CD, Williams J, Pulloor NK, Krishnan MN, Shears SB (2015). "Identification of a functional nuclear translocation sequence in hPPIP5K2" . BMC Cell Biol . 16 : 17. doi :10.1186/s12860-015-0063-7 . PMC 4472268 . PMID 26084399 .
This article incorporates text from the United States National Library of Medicine , which is in the public domain .