PPP2R1B
Identifiers
AliasesPPP2R1B, PP2A-Abeta, PR65B, protein phosphatase 2 scaffold subunit Abeta
External IDsOMIM: 603113 MGI: 1920949 HomoloGene: 70244 GeneCards: PPP2R1B
Orthologs
SpeciesHumanMouse
Entrez

5519

73699

Ensembl

ENSG00000137713

ENSMUSG00000032058

UniProt

P30154

Q7TNP2

RefSeq (mRNA)

NM_001177562
NM_001177563
NM_002716
NM_181699
NM_181700

NM_001034085
NM_001286553
NM_028614

RefSeq (protein)

NP_001171033
NP_001171034
NP_002707
NP_859050
NP_859051

NP_001029257
NP_001273482
NP_082890

Location (UCSC)Chr 11: 111.73 – 111.77 MbChr 9: 50.76 – 50.81 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform is an enzyme that in humans is encoded by the PPP2R1B gene.[5][6][7]

Function

This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes a beta isoform of the constant regulatory subunit A. Defects in this gene could be the cause of some lung and colon cancers. At least two transcript variants encoding different isoforms have been found for this gene.[7]

Interactions

PPP2R1B has been shown to interact with:

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000137713 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032058 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Hemmings BA, Adams-Pearson C, Maurer F, Müller P, Goris J, Merlevede W, Hofsteenge J, Stone SR (Apr 1990). "alpha- and beta-forms of the 65-kDa subunit of protein phosphatase 2A have a similar 39 amino acid repeating structure". Biochemistry. 29 (13): 3166–73. doi:10.1021/bi00465a002. PMID 2159327.
  6. ^ Baysal BE, Farr JE, Goss JR, Devlin B, Richard CW (Sep 1998). "Genomic organization and precise physical location of protein phosphatase 2A regulatory subunit A beta isoform gene on chromosome band 11q23". Gene. 217 (1–2): 107–16. doi:10.1016/S0378-1119(98)00350-3. PMID 9795170.
  7. ^ a b "Entrez Gene: PPP2R1B protein phosphatase 2 (formerly 2A), regulatory subunit A, beta isoform".
  8. ^ a b c d e Zhou J, Pham HT, Ruediger R, Walter G (Jan 2003). "Characterization of the Aalpha and Abeta subunit isoforms of protein phosphatase 2A: differences in expression, subunit interaction, and evolution". The Biochemical Journal. 369 (Pt 2): 387–98. doi:10.1042/BJ20021244. PMC 1223084. PMID 12370081.
  9. ^ a b Goudreault M, D'Ambrosio LM, Kean MJ, Mullin MJ, Larsen BG, Sanchez A, Chaudhry S, Chen GI, Sicheri F, Nesvizhskii AI, Aebersold R, Raught B, Gingras AC (Jan 2009). "A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein". Molecular & Cellular Proteomics. 8 (1): 157–71. doi:10.1074/mcp.M800266-MCP200. PMC 2621004. PMID 18782753.
  10. ^ Kamibayashi C, Lickteig RL, Estes R, Walter G, Mumby MC (Oct 1992). "Expression of the A subunit of protein phosphatase 2A and characterization of its interactions with the catalytic and regulatory subunits". The Journal of Biological Chemistry. 267 (30): 21864–72. doi:10.1016/S0021-9258(19)36692-X. PMID 1328247.
  11. ^ a b c d e McCright B, Rivers AM, Audlin S, Virshup DM (Sep 1996). "The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm". The Journal of Biological Chemistry. 271 (36): 22081–9. doi:10.1074/jbc.271.36.22081. PMID 8703017.

Further reading


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