PPP2R2C
Identifiers
Aliases	PPP2R2C, B55-GAMMA, IMYPNO, IMYPNO1, PR52, PR55G, protein phosphatase 2 regulatory subunit Bgamma, B55gamma
External IDs	OMIM: 605997 MGI: 2442660 HomoloGene: 36386 GeneCards: PPP2R2C
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4p16.1 Start 6,320,578 bp[1] End 6,563,600 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 B3 Start 37,025,857 bp[2] End 37,112,422 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in middle temporal gyrus Brodmann area 46 superior frontal gyrus parietal lobe postcentral gyrus occipital lobe Brodmann area 23 entorhinal cortex prefrontal cortex inferior ganglion of vagus nerve Top expressed in visual cortex superior frontal gyrus primary motor cortex piriform cortex prefrontal cortex cingulate gyrus olfactory tubercle cerebellar cortex nucleus accumbens amygdala More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding protein serine/threonine phosphatase activity protein phosphatase regulator activity Cellular component protein phosphatase type 2A complex cytosol Biological process mitotic cell cycle peptidyl-serine dephosphorylation developmental process regulation of phosphoprotein phosphatase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5522 269643 Ensembl ENSG00000074211 ENSMUSG00000029120 UniProt Q9Y2T4 Q8BG02 RefSeq (mRNA) NM_001206994 NM_001206995 NM_001206996 NM_020416 NM_181876 NM_001363388 NM_172994 NM_001360003 RefSeq (protein) NP_001193923 NP_001193924 NP_001193925 NP_065149 NP_870991 NP_001350317 NP_766582 NP_001346932 Location (UCSC) Chr 4: 6.32 – 6.56 Mb Chr 5: 37.03 – 37.11 Mb PubMed search [3] [4]
Wikidata
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Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform is an enzyme that in humans is encoded by the PPP2R2C gene.^[5][6][7]

Function

The product of this gene belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a gamma isoform of the regulatory subunit B55 subfamily. Alternatively spliced transcript variants encoding different isoforms have been identified.^[7]