PPP2R3B
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifiers
AliasesPPP2R3B, NYREN8, PPP2R3L, PPP2R3LY, PR48, protein phosphatase 2 regulatory subunit B''beta, PR70
External IDsOMIM: 300339 HomoloGene: 61474 GeneCards: PPP2R3B
Orthologs
SpeciesHumanMouse
Entrez

28227

n/a

Ensembl

ENSG00000276438
ENSG00000273850
ENSG00000167393

n/a

UniProt

Q9Y5P8

n/a

RefSeq (mRNA)

NM_013239
NM_199326

n/a

RefSeq (protein)

NP_037371

n/a

Location (UCSC)Chr X: 0.33 – 0.39 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta is an enzyme that in humans is encoded by the PPP2R3B gene.[3][4]

Function

Protein phosphatase 2 (formerly named type 2A) is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2 holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B'' family. The B'' family has been further divided into subfamilies. The product of this gene belongs to the beta subfamily of regulatory subunit B''. Alternative splicing results in multiple transcript variants encoding different isoforms.[4]

Interactions

PPP2R3B has been shown to interact with PPP2R1B,[5] PPP2R1A,[5][6] CDC6[7] and PPP2CA.[6][7]

References

  1. ^ a b c ENSG00000273850, ENSG00000167393 GRCh38: Ensembl release 89: ENSG00000276438, ENSG00000273850, ENSG00000167393 - Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ Schiebel K, Meder J, Rump A, Rosenthal A, Winkelmann M, Fischer C, Bonk T, Humeny A, Rappold G (February 2001). "Elevated DNA sequence diversity in the genomic region of the phosphatase PPP2R3L gene in the human pseudoautosomal region". Cytogenetics and Cell Genetics. 91 (1–4): 224–30. doi:10.1159/000056849. PMID 11173861. S2CID 536348.
  4. ^ a b "Entrez Gene: PPP2R3B protein phosphatase 2 (formerly 2A), regulatory subunit B, beta".
  5. ^ a b Zhou J, Pham HT, Ruediger R, Walter G (Jan 2003). "Characterization of the Aalpha and Abeta subunit isoforms of protein phosphatase 2A: differences in expression, subunit interaction, and evolution". The Biochemical Journal. 369 (Pt 2): 387–98. doi:10.1042/BJ20021244. PMC 1223084. PMID 12370081.
  6. ^ a b Goudreault M, D'Ambrosio LM, Kean MJ, Mullin MJ, Larsen BG, Sanchez A, Chaudhry S, Chen GI, Sicheri F, Nesvizhskii AI, Aebersold R, Raught B, Gingras AC (Jan 2009). "A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein". Molecular & Cellular Proteomics. 8 (1): 157–71. doi:10.1074/mcp.M800266-MCP200. PMC 2621004. PMID 18782753.
  7. ^ a b Yan Z, Fedorov SA, Mumby MC, Williams RS (Feb 2000). "PR48, a novel regulatory subunit of protein phosphatase 2A, interacts with Cdc6 and modulates DNA replication in human cells". Molecular and Cellular Biology. 20 (3): 1021–9. doi:10.1128/MCB.20.3.1021-1029.2000. PMC 85219. PMID 10629059.

Further reading


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