PRPF6
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPRPF6, ANT-1, ANT1, C20orf14, Prp6, RP60, SNRNP102, TOM, U5-102K, hPrp6, pre-mRNA processing factor 6
External IDsOMIM: 613979 MGI: 1922946 HomoloGene: 5368 GeneCards: PRPF6
Orthologs
SpeciesHumanMouse
Entrez

24148

68879

Ensembl

ENSG00000101161

ENSMUSG00000002455

UniProt

O94906

Q91YR7

RefSeq (mRNA)

NM_012469

NM_133701

RefSeq (protein)

NP_036601

NP_598462

Location (UCSC)Chr 20: 63.98 – 64.03 MbChr 2: 181.23 – 181.3 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Pre-mRNA-processing factor 6 is a protein that in humans is encoded by the PRPF6 gene.[5][6][7]

The protein encoded by this gene appears to be involved in pre-mRNA splicing, possibly acting as a bridging factor between U5 and U4/U6 snRNPs in formation of the spliceosome. The encoded protein also can bind androgen receptor, providing a link between transcriptional activation and splicing.[7]

Interactions

PRPF6 has been shown to interact with TXNL4B,[8] ARAF[9][10] and Androgen receptor.[11]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000101161 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000002455 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Nishikimi A, Mukai J, Kioka N, Yamada M (January 2000). "A novel mammalian nuclear protein similar to Schizosaccharomyces pombe Prp1p/Zer1p and Saccharomyces cerevisiae Prp6p pre-mRNA splicing factors". Biochim Biophys Acta. 1435 (1–2): 147–52. doi:10.1016/s0167-4838(99)00203-4. PMID 10561546.
  6. ^ Makarov EM, Makarova OV, Achsel T, Luhrmann R (June 2000). "The human homologue of the yeast splicing factor prp6p contains multiple TPR elements and is stably associated with the U5 snRNP via protein-protein interactions". J Mol Biol. 298 (4): 567–75. doi:10.1006/jmbi.2000.3685. PMID 10788320.
  7. ^ a b "Entrez Gene: PRPF6 PRP6 pre-mRNA processing factor 6 homolog (S. cerevisiae)".
  8. ^ Sun, Xiaojing; Zhang Hua; Wang Dan; Ma Dalong; Shen Yan; Shang Yongfeng (July 2004). "DLP, a novel Dim1 family protein implicated in pre-mRNA splicing and cell cycle progression". J. Biol. Chem. 279 (31). United States: 32839–47. doi:10.1074/jbc.M402522200. ISSN 0021-9258. PMID 15161931.
  9. ^ Yuryev, Anton; Wennogle Lawrence P (February 2003). "Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid analysis". Genomics. 81 (2). United States: 112–25. doi:10.1016/S0888-7543(02)00008-3. ISSN 0888-7543. PMID 12620389.
  10. ^ Yuryev, A; Ono M; Goff S A; Macaluso F; Wennogle L P (July 2000). "Isoform-specific localization of A-RAF in mitochondria". Mol. Cell. Biol. 20 (13). UNITED STATES: 4870–8. doi:10.1128/MCB.20.13.4870-4878.2000. ISSN 0270-7306. PMC 85938. PMID 10848612.
  11. ^ Zhao, Yue; Goto Kiminobu; Saitoh Masayuki; Yanase Toshihiko; Nomura Masatoshi; Okabe Taijiro; Takayanagi Ryoichi; Nawata Hajime (August 2002). "Activation function-1 domain of androgen receptor contributes to the interaction between subnuclear splicing factor compartment and nuclear receptor compartment. Identification of the p102 U5 small nuclear ribonucleoprotein particle-binding protein as a coactivator for the receptor". J. Biol. Chem. 277 (33). United States: 30031–9. doi:10.1074/jbc.M203811200. ISSN 0021-9258. PMID 12039962.

Further reading

External links

Post-transcriptional modification
Categories