PTPN3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2B49, 4QUM, 4QUN, 4RH5, 4RH9, 4RHG, 4RI4, 4RI5, 4S0G
Identifiers
Aliases	PTPN3, PTP-H1, PTPH1, protein tyrosine phosphatase, non-receptor type 3, protein tyrosine phosphatase non-receptor type 3
External IDs	OMIM: 176877 MGI: 105307 HomoloGene: 74451 GeneCards: PTPN3
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q31.3 Start 109,375,466 bp[1] End 109,498,313 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4 B3|4 31.66 cM Start 57,190,841 bp[2] End 57,301,837 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte secondary oocyte triceps brachii muscle thoracic diaphragm gastrocnemius muscle biceps brachii vastus lateralis muscle right lobe of liver amniotic fluid corpus epididymis Top expressed in medial dorsal nucleus medial geniculate nucleus lateral geniculate nucleus trigeminal ganglion ankle otolith organ utricle soleus muscle tibialis anterior muscle olfactory epithelium More reference expression data BioGPS More reference expression data
Gene ontology Molecular function sodium channel regulator activity phosphoprotein phosphatase activity phosphatase activity phosphotyrosine residue binding ATPase binding cytoskeletal protein binding protein binding protein tyrosine phosphatase activity hydrolase activity Cellular component cytoplasm membrane cytoplasmic side of plasma membrane cytoskeleton plasma membrane Biological process regulation of membrane depolarization during action potential protein dephosphorylation liver regeneration regulation of sodium ion transmembrane transporter activity negative regulation of membrane protein ectodomain proteolysis negative regulation of mitotic cell cycle dephosphorylation peptidyl-tyrosine dephosphorylation negative regulation of epidermal growth factor receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5774 545622 Ensembl ENSG00000070159 ENSMUSG00000038764 UniProt P26045 A2ALK8 RefSeq (mRNA) NM_001145368 NM_001145369 NM_001145370 NM_001145371 NM_001145372 NM_002829 NM_011207 NM_001384115 RefSeq (protein) NP_001138840 NP_001138841 NP_001138842 NP_001138843 NP_001138844 NP_002820 NP_035337 NP_001371044 Location (UCSC) Chr 9: 109.38 – 109.5 Mb Chr 4: 57.19 – 57.3 Mb PubMed search [3] [4]
Wikidata
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Tyrosine-protein phosphatase non-receptor type 3 is an enzyme that in humans is encoded by the PTPN3 gene.^[5][6]

Function

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This protein contains a C-terminal PTP domain and an N-terminal domain homologous to the band 4.1 superfamily of cytoskeletal-associated proteins. P97, a cell cycle regulator involved in a variety of membrane related functions, has been shown to be a substrate of this PTP. This PTP was also found to interact with, and be regulated by adaptor protein 14-3-3 beta.^[6]

Interactions

PTPN3 has been shown to interact with YWHAB.^[7]