PTPN7
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPTPN7, BPTP-4, HEPTP, LC-PTP, LPTP, PTPNI, protein tyrosine phosphatase, non-receptor type 7, protein tyrosine phosphatase non-receptor type 7
External IDsOMIM: 176889 MGI: 2156893 HomoloGene: 15411 GeneCards: PTPN7
Orthologs
SpeciesHumanMouse
Entrez

5778

320139

Ensembl

ENSG00000143851

ENSMUSG00000031506

UniProt

P35236

Q8BUM3

RefSeq (mRNA)

NM_177081
NM_001356382

RefSeq (protein)

NP_001186726
NP_002823
NP_542155
NP_001351806
NP_001351807

NP_796055
NP_001343311

Location (UCSC)Chr 1: 202.15 – 202.16 MbChr 1: 135.06 – 135.07 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Protein tyrosine phosphatase non-receptor type 7 is an enzyme that in humans is encoded by the PTPN7 gene.[5][6]

Function

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This gene is preferentially expressed in a variety of hematopoietic cells, and is an early response gene in lymphokine stimulated cells. The noncatalytic N-terminus of this PTP can interact with MAP kinases and suppress the MAP kinase activities. This PTP was shown to be involved in the regulation of T cell antigen receptor (TCR) signaling, which was thought to function through dephosphorylating the molecules related to MAP kinase pathway. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene.[6]

Interactions

PTPN7 has been shown to interact with MAPK3[7][8][9] and MAPK1.[7][9]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000143851 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031506 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Adachi M, Sekiya M, Isobe M, Kumura Y, Ogita Z, Hinoda Y, Imai K, Yachi A (September 1992). "Molecular cloning and chromosomal mapping of a human protein-tyrosine phosphatase LC-PTP". Biochem Biophys Res Commun. 186 (3): 1607–15. doi:10.1016/S0006-291X(05)81592-X. PMID 1510684.
  6. ^ a b "Entrez Gene: PTPN7 protein tyrosine phosphatase, non-receptor type 7".
  7. ^ a b Pettiford SM, Herbst R (February 2000). "The MAP-kinase ERK2 is a specific substrate of the protein tyrosine phosphatase HePTP". Oncogene. 19 (7): 858–69. doi:10.1038/sj.onc.1203408. PMID 10702794. S2CID 24843974.
  8. ^ Saxena M, Williams S, Taskén K, Mustelin T (September 1999). "Crosstalk between cAMP-dependent kinase and MAP kinase through a protein tyrosine phosphatase". Nat. Cell Biol. 1 (5): 305–11. doi:10.1038/13024. PMID 10559944. S2CID 40413956.
  9. ^ a b Saxena M, Williams S, Brockdorff J, Gilman J, Mustelin T (April 1999). "Inhibition of T cell signaling by mitogen-activated protein kinase-targeted hematopoietic tyrosine phosphatase (HePTP)". J. Biol. Chem. 274 (17): 11693–700. doi:10.1074/jbc.274.17.11693. PMID 10206983.

Further reading


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