PTPRA
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1P15, 1YFO
Identifiers
Aliases	PTPRA, HEPTP, HLPR, HPTPA, HPTPalpha, LRP, PTPA, PTPRL2, R-PTP-alpha, RPTPA, protein tyrosine phosphatase, receptor type A, protein tyrosine phosphatase receptor type A
External IDs	OMIM: 176884 MGI: 97808 HomoloGene: 20621 GeneCards: PTPRA
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20p13 Start 2,864,184 bp[1] End 3,039,076 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2 F1|2 63.23 cM Start 130,292,198 bp[2] End 130,398,044 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon ganglionic eminence prefrontal cortex nucleus accumbens amygdala cingulate gyrus caudate nucleus Brodmann area 9 corpus callosum hypothalamus Top expressed in superior frontal gyrus subiculum cerebellar cortex nucleus accumbens calvaria hippocampus proper prefrontal cortex dermis ganglionic eminence olfactory tubercle More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding phosphatase activity protein tyrosine phosphatase activity phosphoprotein phosphatase activity transmembrane receptor protein tyrosine phosphatase activity hydrolase activity Cellular component receptor complex integral component of plasma membrane integral component of membrane membrane extracellular exosome plasma membrane intracellular anatomical structure Schaffer collateral - CA1 synapse integral component of synaptic membrane Biological process dephosphorylation axon guidance protein phosphorylation protein dephosphorylation MAPK cascade peptidyl-tyrosine dephosphorylation insulin receptor signaling pathway regulation of molecular function modulation of chemical synaptic transmission Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5786 19262 Ensembl ENSG00000132670 ENSMUSG00000027303 UniProt P18433 Q5JWG0 P18052 RefSeq (mRNA) NM_080841 NM_002836 NM_080840 NM_001163688 NM_008980 NM_001355161 RefSeq (protein) NP_002827 NP_543030 NP_543031 NP_001157160 NP_033006 NP_001342090 Location (UCSC) Chr 20: 2.86 – 3.04 Mb Chr 2: 130.29 – 130.4 Mb PubMed search [3] [4]
Wikidata
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Receptor-type tyrosine-protein phosphatase alpha is an enzyme that in humans is encoded by the PTPRA gene.^[5][6][7]

Function

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. This PTP has been shown to dephosphorylate and activate Src family tyrosine kinases,^[8] and is implicated in the regulation of integrin signaling, cell adhesion and proliferation. Three alternatively spliced variants of this gene, which encode two distinct isoforms, have been reported.^[7]

Interactions

PTPRA has been shown to interact with Grb2^[9][10][11] and KCNA2.^[12]