PTPRE
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2JJD
Identifiers
Aliases	PTPRE, HPTPE, PTPE, R-PTP-EPSILON, protein tyrosine phosphatase, receptor type E, protein tyrosine phosphatase receptor type E
External IDs	OMIM: 600926 MGI: 97813 HomoloGene: 31387 GeneCards: PTPRE
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q26.2 Start 127,907,103 bp[1] End 128,085,855 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 F3|7 81.27 cM Start 135,139,210 bp[2] End 135,288,022 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte blood bone marrow cells sural nerve visceral pleura trigeminal ganglion right lung appendix upper lobe of left lung Region I of hippocampus proper Top expressed in sciatic nerve subiculum olfactory tubercle bone marrow right lung lobe dentate gyrus entorhinal cortex amygdala ventromedial nucleus ventral tegmental area More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein tyrosine phosphatase activity phosphatase activity transmembrane receptor protein tyrosine phosphatase activity protein binding phosphoprotein phosphatase activity hydrolase activity Cellular component cytoplasm integral component of membrane plasma membrane membrane nucleus Biological process negative regulation of insulin receptor signaling pathway protein dephosphorylation peptidyl-tyrosine dephosphorylation dephosphorylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5791 19267 Ensembl ENSG00000132334 ENSMUSG00000041836 UniProt P23469 P49446 RefSeq (mRNA) NM_006504 NM_130435 NM_001316676 NM_001316677 NM_001323354 NM_001323355 NM_001323356 NM_001323357 NM_011212 NM_001316678 NM_001316679 NM_001316680 NM_001316681 RefSeq (protein) NP_001303605 NP_001303606 NP_001310283 NP_001310284 NP_001310285 NP_001310286 NP_006495 NP_569119 NP_001303607 NP_001303608 NP_001303609 NP_001303610 NP_035342 Location (UCSC) Chr 10: 127.91 – 128.09 Mb Chr 7: 135.14 – 135.29 Mb PubMed search [3] [4]
Wikidata
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Receptor-type tyrosine-protein phosphatase epsilon is an enzyme that in humans is encoded by the PTPRE gene.^[5][6]

Function

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Two alternatively spliced transcript variants of this gene have been reported, one of which encodes a receptor-type PTP that possesses a short extracellular domain, a single transmembrane region, and two tandem intracytoplasmic catalytic domains; Another one encodes a PTP that contains a distinct hydrophilic N-terminus, and thus represents a nonreceptor-type isoform of this PTP. Studies of the similar gene in mice suggested the regulatory roles of this PTP in RAS related signal transduction pathways, cytokines induced SATA signaling, as well as the activation of voltage-gated K+ channels.^[6]

Interactions

PTPRE has been shown to interact with KCNB1.^[7]