PTPRH
Identifiers
Aliases	PTPRH, R-PTP-H, SAP1, protein tyrosine phosphatase, receptor type H, protein tyrosine phosphatase receptor type H
External IDs	OMIM: 602510 MGI: 3026877 HomoloGene: 37693 GeneCards: PTPRH
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.42 Start 55,181,247 bp[1] End 55,209,506 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 A1 Start 4,551,611 bp[2] End 4,607,040 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in jejunal mucosa duodenum pancreatic ductal cell gallbladder rectum islet of Langerhans oocyte spleen secondary oocyte right adrenal gland Top expressed in jejunum ileum colon duodenum stomach superior frontal gyrus cerebellar cortex hypothalamus pancreas kidney More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein tyrosine phosphatase activity phosphatase activity transmembrane receptor protein tyrosine phosphatase activity protein binding phosphoprotein phosphatase activity hydrolase activity Cellular component cytoplasm integral component of membrane integral component of plasma membrane membrane plasma membrane microvillus apical plasma membrane microvillus membrane cell projection Biological process protein dephosphorylation dephosphorylation apoptotic process peptidyl-tyrosine dephosphorylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5794 545902 Ensembl ENSG00000080031 ENSMUSG00000035429 UniProt Q9HD43 E9Q0N2 RefSeq (mRNA) NM_001161440 NM_002842 NM_207270 RefSeq (protein) NP_001154912 NP_002833 NP_997153 Location (UCSC) Chr 19: 55.18 – 55.21 Mb Chr 7: 4.55 – 4.61 Mb PubMed search [3] [4]
Wikidata
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Receptor-type tyrosine-protein phosphatase H is an enzyme that in humans is encoded by the PTPRH gene.^[5][6]

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single intracytoplasmic catalytic domain, and thus represents a receptor-type PTP. The extracellular region contains eight fibronectin type III-like repeats and multiple N-glycosylation sites. The gene was shown to be expressed primarily in brain and liver, and at a lower level in heart and stomach. It was also found to be expressed in several cancer cell lines, but not in the corresponding normal tissues.^[6]