PTPRJ
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2CFV, 2DLE, 2NZ6
Identifiers
Aliases	PTPRJ, CD148, DEP1, HPTPeta, R-PTP-ETA, SCC1, protein tyrosine phosphatase, receptor type J, protein tyrosine phosphatase receptor type J, R-PTP-J, HPTP eta
External IDs	OMIM: 600925 MGI: 104574 HomoloGene: 2130 GeneCards: PTPRJ
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11p11.2 Start 47,980,559 bp[1] End 48,170,839 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2 E1|2 50.19 cM Start 90,260,098 bp[2] End 90,410,991 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte blood parotid gland renal medulla pylorus bone marrow cells palpebral conjunctiva jejunal mucosa internal globus pallidus cardia Top expressed in olfactory tubercle dentate gyrus primary motor cortex lateral geniculate nucleus piriform cortex ascending aorta blood cingulate gyrus lacrimal gland superior frontal gyrus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function beta-catenin binding phosphoprotein phosphatase activity gamma-catenin binding phosphatase activity delta-catenin binding mitogen-activated protein kinase binding platelet-derived growth factor receptor binding protein binding hydrolase activity protein kinase binding protein tyrosine phosphatase activity Cellular component integral component of membrane cell projection membrane cell-cell junction plasma membrane integral component of plasma membrane ruffle membrane cell surface cell junction immunological synapse extracellular exosome specific granule membrane Biological process negative regulation of platelet-derived growth factor receptor signaling pathway negative regulation of protein kinase B signaling positive regulation of protein kinase B signaling negative regulation of epidermal growth factor receptor signaling pathway protein dephosphorylation contact inhibition negative regulation of T cell receptor signaling pathway regulation of cell adhesion negative regulation of cell migration negative regulation of MAP kinase activity negative regulation of cell growth positive regulation of focal adhesion assembly platelet-derived growth factor receptor signaling pathway positive chemotaxis peptidyl-tyrosine dephosphorylation T cell receptor signaling pathway negative regulation of cell population proliferation negative regulation of vascular permeability positive regulation of cell adhesion dephosphorylation neutrophil degranulation B cell differentiation positive regulation of tumor necrosis factor production calcium-mediated signaling using intracellular calcium source positive regulation of MAPK cascade positive regulation of peptidyl-tyrosine phosphorylation positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5795 19271 Ensembl ENSG00000149177 ENSMUSG00000025314 UniProt Q12913 Q64455 RefSeq (mRNA) NM_001098503 NM_002843 NM_001135657 NM_008982 RefSeq (protein) NP_001091973 NP_002834 NP_001129129 NP_033008 Location (UCSC) Chr 11: 47.98 – 48.17 Mb Chr 2: 90.26 – 90.41 Mb PubMed search [3] [4]
Wikidata
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Receptor-type tyrosine-protein phosphatase eta is an enzyme that in humans is encoded by the PTPRJ gene.^[5][6][7]

Function

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region containing five fibronectin type III repeats, a single transmembrane region, and a single intracytoplasmic catalytic domain, and thus represents a receptor-type PTP. This PTP is present in all hematopoietic lineages, and was shown to negatively regulate T cell receptor signaling possibly through interfering with the phosphorylation of Phospholipase C Gamma 1 (PLCG1) and Linker for Activation of T Cells (LAT). This PTP was also found to dephosphorylate PDGF beta receptor, and may be involved in UV-induced signal transduction.^[7]

Interactions

PTPRJ has been shown to interact with CTNND1.^[8]