PTPRR
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2A8B
Identifiers
Aliases	PTPRR, EC-PTP, PCPTP1, PTP-SL, PTPBR7, PTPRQ, protein tyrosine phosphatase, receptor type R, protein tyrosine phosphatase receptor type R
External IDs	OMIM: 602853 MGI: 109559 HomoloGene: 2135 GeneCards: PTPRR
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q15 Start 70,638,073 bp[1] End 70,920,738 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 D2 Start 115,854,118 bp[2] End 116,110,837 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell prefrontal cortex entorhinal cortex jejunal mucosa Brodmann area 46 orbitofrontal cortex cerebellar vermis middle temporal gyrus dorsolateral prefrontal cortex Brodmann area 9 Top expressed in secondary oocyte entorhinal cortex jejunum olfactory epithelium cerebellar vermis corneal stroma trigeminal ganglion plantaris muscle large intestine colon More reference expression data BioGPS More reference expression data
Gene ontology Molecular function phosphoprotein phosphatase activity phosphatase activity protein binding protein tyrosine phosphatase activity transmembrane receptor protein tyrosine phosphatase activity protein kinase binding hydrolase activity Cellular component integral component of membrane membrane plasma membrane cell junction perinuclear region of cytoplasm extracellular space cytoplasm cytosol Biological process protein dephosphorylation in utero embryonic development ERBB2 signaling pathway regulation of homophilic cell adhesion negative regulation of ERK1 and ERK2 cascade peptidyl-tyrosine dephosphorylation negative regulation of epithelial cell migration dephosphorylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5801 19279 Ensembl ENSG00000153233 ENSMUSG00000020151 UniProt Q15256 Q62132 RefSeq (mRNA) NM_001207015 NM_001207016 NM_002849 NM_130846 NM_001161837 NM_001161838 NM_001161839 NM_001161840 NM_011217 NM_001358484 RefSeq (protein) NP_001193944 NP_001193945 NP_002840 NP_570897 NP_001155309 NP_001155310 NP_001155311 NP_001155312 NP_035347 NP_001345413 Location (UCSC) Chr 12: 70.64 – 70.92 Mb Chr 10: 115.85 – 116.11 Mb PubMed search [3] [4]
Wikidata
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Protein tyrosine phosphatase receptor-type R is an enzyme that in humans is encoded by the PTPRR gene.^[5][6][7]

Function

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single intracellular catalytic domains, and thus represents a receptor-type PTP. The similar gene predominantly expressed in mouse brain was found to associate with, and thus regulate the activity and cellular localization of MAP kinases. The rat counterpart of this gene was reported to be regulated by the nerve growth factor, which suggested the function of this gene in neuronal growth and differentiation.^[7]

Interactions

PTPRR has been shown to interact with MAPK7.^[8]