Protein-coding gene in the species Homo sapiens
Polymerase I and transcript release factor, also known as Cavin1, Cavin-1 or PTRF, is a protein which in humans is encoded by the PTRF gene.[5][6]
Function
PTRF (Cavin1) has been shown to be crucial for caveola formation and function.[7] Deformation caveolae promotes the translocation of cavin-1 from caveolae to the nucleus[8]
Termination of RNA polymerase I catalyzed transcription is a 2-step process that involves pausing of transcription elongation and release of both the pre-ribosomal RNA and Pol I from the DNA template. The pausing is mediated by TTF1 and PTRF.[9][10]
PTRF is a soluble protein containing putative leucine zipper, nuclear localization signal, and PEST domains.[11]
Interactions
PTRF (Cavin1) forms trimers with Cavin2 and Cavin3 in caveola formation and has been shown to interact with other membrane associating proteins such as EHD2 and caveolins.[12]
PTRF has been shown to interact with ZNF148.[13]