Patti is an Italian surname. Notable people with the surname include:

• Adelina Patti (1843–1919), Italian-French opera singer
• Antonino da Patti, Sicilian priest
• Archimedes Patti (1913 – 1998), lieutenant colonel in the United States Army and an Office of Strategic Services
• Carlotta Patti (c. 1840 – 1889), Italian operatic soprano and older sister to famed soprano Adelina Patti
• Carmelo Patti (c. 1934 – 2016), Italian businessman with close links to the Mafia
• Cathy Gentile-Patti (born 1962), American para-alpine skier
• Dino Patti Djalal (born 1965), former Indonesian ambassador to the United States
• Ercole Patti (1903–1976), Italian author, dramatist, screenwriter and journalist
• Guesch Patti (born 1946), French singer
• Leonardo Patti (born 1978), Argentine volleyball player
• Luis Patti (born 1952), Argentine politician and a former senior police officer
• Tom Patti (born 1963), American businessman and politician