Peroxiredoxin-1 is a protein that in humans is encoded by the PRDX1 gene.[5][6]
Peroxiredoxin-1 is a protein that in humans is encoded by the PRDX1 gene.[5][6]
This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides.[7] The encoded protein may play an antioxidant protective role in cells, and may contribute to the antiviral activity of CD8(+) T-cells. This protein may have a proliferative effect and play a role in cancer development or progression. Three transcript variants encoding the same protein have been identified for this gene.[6]
Peroxiredoxin 1 has been shown to interact with PRDX4.[8] A chemoproteomic approach has revealed that peroxiredoxin 1 is the main target of theonellasterone.[9]
As enzymes that combat oxidative stress, peroxiredoxins play an important role in health and disease.[10] Peroxiredoxin 1 and peroxiredoxin 2 have been shown to be released by some cells when stimulated by LPS or TNF-alpha.[11] The released peroxiredoxin can then act to produce inflammatory cytokines.[11] The levels of peroxiredoxin 1 are elevated in pancreatic cancer and it can potentially act as a marker for the diagnosis and prognosis of this disease.[12] In some types of cancer, peroxiredoxin 1 has been determined to act as a tumor suppressor and other studies show that peroxiredoxin 1 is overexpressed in certain human cancers.[13] A recent study has found that peroxiredoxin 1 may play a role in tumorigenesis by regulating the mTOR/p70S6K pathway in esophageal squamous cell carcinoma.[13] The expression patterns of peroxiredoxin 1 along with peroxiredoxin 4 are involved in human lung cancer malignancy.[14] It has also been shown that peroxiredoxin 1 may be an important player in the pathogenesis of acute respiratory distress syndrome because of its role in promoting inflammation.[15]
