In Greek mythology, the name Polypheides or Polyphides (/ˌpɒlɪˈfaɪdiːz/; Ancient Greek: Πολυφείδης) may refer to:

• Polypheides, son of Mantius and brother of Cleitus. He was granted prophetic skills by Apollo and became the best seer among mortals after the death of Amphiaraus; he dwelt in Hyperesia and had a son Theoclymenus.^[1] A slightly different account of his life was given by Pherecydes:^[2] according to it, Polypheides married Aechme, daughter of Haemon, and settled in Eleusis, where two sons, Theoclymenus and Harmonides, were born to him.
• Polypheides, lord of Sicyon, to whom Agamemnon and Menelaus were entrusted by their nurse or sent by Aegisthus after the murder of Atreus. He further sent them to Oeneus.^[3]