Prasidh first came to the limelight during Bangladesh A's tour of India in 2015, taking 5 for 49 on first-class debut for Karnataka in a tour match against Bangladesh A in the absence of all three frontline Karnataka pace bowlers. He took a wicket off his first ball, dismissing Rony Talukdar, before taking the wickets of Anamul Haque, Soumya Sarkar and Nasir Hossain in his first spell to reduce Bangladesh A to 41/5. Karnataka went on to win the match by 4 wickets.[6][7]
During the 2021-22 Ranji Trophy, Prasidh took his maiden first-class ten-wicket haul against Jammu and Kashmir picking up 6/35 in the first innings and 4/59 in the second innings.[13]
In March 2021, he was named in India's One Day International (ODI) squad for their series against England.[17] He made his ODI debut for India on 23 March 2021, against England.[18] He went on to take 4 wickets, helping India to win the match by 66 runs.[19]
In May 2021, he was named as one of four standby players in India's Test squad for the final of the 2019–2021 ICC World Test Championship and their away series against England.[20][21] In September 2021, he was added to India's main squad for the fourth Test match against England but didn't play.[22]
In February 2022, Prasidh was named in India's Squad for ODIs against West Indies. He was named the man of the match in the second match as he took 4 wickets for 12 runs[23] and went on to win the Man of the Series award with a three-fer in the third game.[24]
In May 2022, he was named in India's Test squad for the rescheduled fifth Test against England.[25]
On 5 November 2023, he was added to India's squad for the 2023 Cricket World Cup after Hardik Pandya was ruled out owing to his ankle injury from the match against Bangladesh on 19 October 2023.[26]
On 28 November 2023, Prasidh Krishna made the record of conceding most runs in a spell in T20 international for India.[27]
