Publius Cornelius Scipio may refer to:

• Publius Cornelius Maluginensis Scipio (consular tribune 395 BC)
• Publius Cornelius Scipio Asina (c. 260 BC–after 211 BC), consul in 221 BC
• Publius Cornelius Scipio (consul 218 BC) (d. 211 BC)
• Publius Cornelius Scipio Africanus, also known as Scipio Africanus
• Publius Cornelius Scipio (son of Scipio Africanus), a historian
• Publius Cornelius Scipio Nasica (consul 191 BC)
• Publius Cornelius Scipio Nasica Corculum
• Publius Cornelius Scipio (flamen Dialis)
• Publius Cornelius Scipio Africanus Aemilianus, also known as Scipio Aemilianus, or Scipio Africanus the Younger
• Publius Cornelius Scipio Nasica Serapio
• Publius Cornelius Scipio Nasica (consul 111 BC)
• Quintus Caecilius Metellus Pius Scipio, formerly Publius Cornelius Scipio Nasica, sometimes known as Metellus Scipio
• Publius Cornelius Scipio (consul 16 BC)