In Greek mythology, Pyrene (Ancient Greek: Πυρήνη) may refer to:

• Pyrene, daughter of King Bebrycius and a lover (or victim, depending on the myth) of Heracles. She bore a serpent and became so terrified that she fled to the woods where she died. Heracles created a tomb for her by piling up rocks thus forming the mountain range of the Pyrenees, named after her.^[1][2][3]
• Pyrene, also called Pelopia, mother of Cycnus with Ares.^[4]