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Anthramycin contains pyrrolobenzodiazepine core

Pyrrolobenzodiazepines, (PBD) are a class of compound that may have antibiotic or anti-tumor properties.[1]

Some dimeric pyrrolobenzodiazepines are used as the cytotoxic drug payloads in antibody-drug conjugates, for example in loncastuximab tesirine.

History

Anthramycin, the first PBD monomer, was first synthesized in the 1960s.[2]

References

  1. ^ Hartley JA (June 2011). "The development of pyrrolobenzodiazepines as antitumour agents". Expert Opinion on Investigational Drugs. 20 (6): 733–44. doi:10.1517/13543784.2011.573477. PMID 21457108. S2CID 26275418.
  2. ^ From Anthramycin to Pyrrolobenzodiazepine (PBD)‐Containing Antibody–Drug Conjugates (ADCs) Angew Chem Int Ed Engl. 2017 Jan 9; 56(2): 462–488. Published online 2016 Nov 15. doi: 10.1002/anie.201510610
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