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QazCovid-in, commercially known as QazVac,^[1][2] is a COVID-19 vaccine developed by the Research Institute for Biological Safety Problems in Kazakhstan.^[3][4] QazCoVac-P is a second COVID-19 vaccine developed by the Kazakh Biosafety Research Institute and in clinical trials.^[5]

Manufacturing

The vaccine can be stored at standard refrigeration temperatures (2 °C-8 °C) and is a two-dose régime with the doses administered twenty-one days apart.^[6] The vaccine was first manufactured by Kazakhstan's Research Institute of Biological Safety Problems. Production capacity has been capped at 50,000 doses per month.^{[citation needed]}

Beginning in June 2021, the vaccine is slated^[7] to be packaged in large bulk to be bottled in Turkey by a major Turkish company.^[8] This will allow for a production capacity of 500,000-600,000 doses per month.^[9] The contract is still being negotiated,^[10] despite earlier claims suggesting that the deal had already been finalized.^[11][12]

In October 2021, it was announced that the vaccine would be supplied to Afghanistan and other countries in 2022.^[13]

History

Clinical trials

In September 2020, QazVac started in Phase I/II clinical trials.^[14]

In December 2020, QazVac is currently in Phase III clinical trials, which is expected to be fully completed by 9 July 2021.^[2][8] It is unclear when the first preliminary results will be published.^[15][12]

The administration of the vaccine for the general population began at the end of April 2021.^[16] The Research Institute Kunsulu Zakarya's Director General's justification is that the trial is almost 50% completed and "people who have received [the] vaccine feel well; there have been no side-effects and the effectiveness of the vaccine is high".^[8]

In September 2021, a study was published to eClinicalMedicine, published by The Lancet. The study’s findings were that the “QazCovid-in® vaccine was safe and well-tolerated and induced predominantly mild adverse events; no serious or severe adverse events were recorded in both trials.” ^[17]

Authorization

Economics

The first batch of 50,000 doses was delivered on 26 April 2021, and vaccination began shortly after.^{[citation needed]} In June 2021, the capacity will increase to 100,000 doses per month, regardless of the contract for bottling in Turkey.^[18]