Route 216
Route information
Maintained by Transports Québec
Length	315.5 km[1] (196.0 mi)
Major junctions
West end	R-108 in Sainte-Catherine-de-Hatley
Major intersections	A-610 / A-410 / R-112 / R-143 in Sherbrooke R-255 in Saint-Camille & Wotton R-257 in Saint-Adrien R-161 in Ham-Nord R-263 in Saint-Jacques-le-Majeur-de-Wolfestown R-165 in Irlande R-267 in Saint-Jean-de-Brébeuf R-269 in Kinnear's Mills R-269 / R-271 in Saint-Jacques-de-Leeds A-73 / R-173 in Sainte-Marie R-275 in Sainte-Marguerite R-277 in Saint-Malachie R-279 in Notre-Dame-Auxiliatrice-du-Buckland R-281 in Saint-Philémon R-283 in Saint-Paul-de-Montminy R-285 in Saint-Marcel
East end	R-204 in Sainte-Perpétue
Location
Country	Canada
Province	Quebec
Highway system
Quebec provincial highways Autoroutes List Former
← R-215 → R-217

Route 216 is a two-lane east/west highway in Quebec, Canada, which starts in Sainte-Catherine-de-Hatley in the Estrie region at the junction of Route 108 and ends in Sainte-Perpétue in Chaudière-Appalaches at the junction of Route 204.

Route 216 follows mostly a northeast/southwest course, and it is not a busy highway as it mostly links small villages between themselves in the backroads of the Appalachians. The only two major towns along the way are Sherbrooke and Sainte-Marie. Between Ham-Nord (junction with Route 161) and Saint-Jacques-le-Majeur-de-Wolfestown (junction with Route 263), the road is unpaved.

Municipalities along Route 216

• Sainte-Catherine-de-Hatley
• Sherbrooke
• Stoke
• Saint-Camille
• Wotton
• Saint-Adrien
• Ham-Nord
• Saint-Jacques-le-Majeur-de-Wolfestown
• Saint-Julien
• Irlande
• Saint-Adrien-d'Irlande
• Saint-Jean-de-Brébeuf
• Kinnear's Mills
• Saint-Jacques-de-Leeds
• Saint-Sylvestre
• Saint-Elzéar
• Sainte-Marie
• Sainte-Marguerite
• Saint-Malachie
• Saint-Nazaire-de-Dorchester
• Notre-Dame-Auxiliatrice-du-Buckland
• Saint-Philémon
• Saint-Paul-de-Montminy
• Sainte-Apolline-de-Patton
• Saint-Marcel
• Sainte-Félicité
• Sainte-Perpétue

• 
  Route 216 in Mont-Bellevue borough, Sherbrooke.
• 
  Route 216 through downtown Sherbrooke.
• 
  Route 216 is the main road to Centre hospitalier universitaire de Sherbrooke.
• 
  Route 216 in Stoke.
• 
  Route 216 in Saint-Jacques-de-Leeds.
• 
  Principale street in à Saint-Sylvestre.
• 
  Route 216 in Sainte-Félicité.
• 
  Route 216 in Saint-Marcel.