RAB11FIP3

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2D7C, 2HV8, 4D0M, 4UJ3, 4UJ4

Identifiers

Aliases

RAB11FIP3, CART1, Rab11-FIP3, RAB11 family interacting protein 3, FIP3-Rab11

External IDs

OMIM: 608738 MGI: 2444431 HomoloGene: 49396 GeneCards: RAB11FIP3

Gene location (Human)

Chr.	Chromosome 16 (human)^[1]

Band	16p13.3	Start	425,649 bp^[1]
Band	16p13.3	End	523,011 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 17 (mouse)^[2]

Band	17\|17 A3.3	Start	26,208,010 bp^[2]
Band	17\|17 A3.3	End	26,288,529 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

pancreatic ductal cell

kidney

sural nerve

renal medulla

renal cortex

visceral pleura

cingulate gyrus

body of pancreas

pituitary gland

anterior pituitary

Top expressed in

proximal tubule

kidney

knee joint

superior frontal gyrus

skeletal muscle tissue

quadriceps femoris muscle

triceps brachii muscle

cerebellar cortex

temporal muscle

hand

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	calcium ion binding protein homodimerization activity metal ion binding protein binding dynein light intermediate chain binding
Cellular component	cytoplasm recycling endosome cytosol endosome centrosome intracellular membrane-bounded organelle membrane nucleoplasm microtubule organizing center recycling endosome membrane midbody intercellular bridge cleavage furrow cytoskeleton endocytic vesicle
Biological process	cell division endocytic recycling cell cycle negative regulation of adiponectin secretion vesicle-mediated transport cytokinesis regulation of cytokinesis protein localization to cilium
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


9727


215445

Ensembl


ENSG00000090565 ENSG00000275338


ENSMUSG00000037098

UniProt


O75154


Q8CHD8

RefSeq (mRNA)


NM_001142272 NM_014700 NM_001370401


NM_001162868 NM_001162869 NM_153140

RefSeq (protein)


NP_001135744 NP_055515 NP_001357330


NP_001156340 NP_001156341 NP_694780

Location (UCSC)

Chr 16: 0.43 – 0.52 Mb

Chr 17: 26.21 – 26.29 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Rab11 family-interacting protein 3 is a protein that in humans is encoded by the RAB11FIP3 gene.^[5]^[6]^[7]

Proteins of the large Rab GTPase family (see RAB1A; MIM 179508) have regulatory roles in the formation, targeting, and fusion of intracellular transport vesicles. RAB11FIP3 is one of many proteins that interact with and regulate Rab GTPases (Hales et al., 2001).[supplied by OMIM]^[7]

Interactions

RAB11FIP3 has been shown to interact with RAB11A.^[8]

References

Shin OH, Ross AH, Mihai I, Exton JH (2000). "Identification of arfophilin, a target protein for GTP-bound class II ADP-ribosylation factors". J. Biol. Chem. 274 (51): 36609–15. doi:10.1074/jbc.274.51.36609. PMID 10593962.
Daniels RJ, Peden JF, Lloyd C, et al. (2001). "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16". Hum. Mol. Genet. 10 (4): 339–52. doi:10.1093/hmg/10.4.339. PMID 11157797.
Hales CM, Griner R, Hobdy-Henderson KC, et al. (2001). "Identification and characterization of a family of Rab11-interacting proteins". J. Biol. Chem. 276 (42): 39067–75. doi:10.1074/jbc.M104831200. PMID 11495908.
Shin OH, Couvillon AD, Exton JH (2001). "Arfophilin is a common target of both class II and class III ADP-ribosylation factors". Biochemistry. 40 (36): 10846–52. doi:10.1021/bi0107391. PMID 11535061.
Yang CS, Weiner H (2002). "Yeast two-hybrid screening identifies binding partners of human Tom34 that have ATPase activity and form a complex with Tom34 in the cytosol". Arch. Biochem. Biophys. 400 (1): 105–10. doi:10.1006/abbi.2002.2778. PMID 11913976.
Wallace DM, Lindsay AJ, Hendrick AG, McCaffrey MW (2003). "Rab11-FIP4 interacts with Rab11 in a GTP-dependent manner and its overexpression condenses the Rab11 positive compartment in HeLa cells". Biochem. Biophys. Res. Commun. 299 (5): 770–9. doi:10.1016/S0006-291X(02)02720-1. PMID 12470645.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Behrends U, Schneider I, Rössler S, et al. (2003). "Novel tumor antigens identified by autologous antibody screening of childhood medulloblastoma cDNA libraries". Int. J. Cancer. 106 (2): 244–51. doi:10.1002/ijc.11208. PMID 12800201. S2CID 36836051.
Horgan CP, Walsh M, Zurawski TH, McCaffrey MW (2004). "Rab11-FIP3 localises to a Rab11-positive pericentrosomal compartment during interphase and to the cleavage furrow during cytokinesis". Biochem. Biophys. Res. Commun. 319 (1): 83–94. doi:10.1016/j.bbrc.2004.04.157. PMID 15158446.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Wilson GM, Fielding AB, Simon GC, et al. (2005). "The FIP3-Rab11 protein complex regulates recycling endosome targeting to the cleavage furrow during late cytokinesis". Mol. Biol. Cell. 16 (2): 849–60. doi:10.1091/mbc.E04-10-0927. PMC 545916. PMID 15601896.
Martin J, Han C, Gordon LA, et al. (2005). "The sequence and analysis of duplication-rich human chromosome 16". Nature. 432 (7020): 988–94. Bibcode:2004Natur.432..988M. doi:10.1038/nature03187. PMID 15616553.
Shiba T, Koga H, Shin HW, et al. (2007). "Structural basis for Rab11-dependent membrane recruitment of a family of Rab11-interacting protein 3 (FIP3)/Arfophilin-1". Proc. Natl. Acad. Sci. U.S.A. 103 (42): 15416–21. Bibcode:2006PNAS..10315416S. doi:10.1073/pnas.0605357103. PMC 1622838. PMID 17030804.
Horgan CP, Oleksy A, Zhdanov AV, et al. (2007). "Rab11-FIP3 is critical for the structural integrity of the endosomal recycling compartment" (PDF). Traffic. 8 (4): 414–30. doi:10.1111/j.1600-0854.2007.00543.x. PMID 17394487.
Schonteich E, Pilli M, Simon GC, et al. (2007). "Molecular characterization of Rab11-FIP3 binding to ARF GTPases". Eur. J. Cell Biol. 86 (8): 417–31. doi:10.1016/j.ejcb.2007.05.004. PMID 17628206.

v t e PDB gallery
2d7c: Crystal structure of human Rab11 in complex with FIP3 Rab-binding domain 2hv8: Crystal structure of GTP-bound Rab11 in complex with FIP3

Interactions

References

Further reading