RASD2
Identifiers
Aliases	RASD2, MGC:4834, Rhes, TEM2, RASD family member 2
External IDs	OMIM: 612842 MGI: 1922391 HomoloGene: 8628 GeneCards: RASD2
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q12.3 Start 35,540,831 bp[1] End 35,553,999 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 C1 Start 75,940,572 bp[2] End 75,950,741 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in putamen caudate nucleus nucleus accumbens prefrontal cortex Brodmann area 9 cingulate gyrus postcentral gyrus external globus pallidus amygdala hypothalamus Top expressed in superior frontal gyrus nucleus accumbens visual cortex olfactory tubercle substantia nigra gastrocnemius muscle lacrimal gland globus pallidus motor neuron parotid gland More reference expression data BioGPS n/a
Gene ontology Molecular function G-protein beta-subunit binding nucleotide binding GTP binding ubiquitin conjugating enzyme binding phosphatidylinositol 3-kinase binding GTPase activity Cellular component plasma membrane membrane Biological process negative regulation of protein ubiquitination regulation of cAMP-mediated signaling positive regulation of protein kinase B signaling synaptic transmission, dopaminergic positive regulation of protein sumoylation locomotory behavior signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23551 75141 Ensembl ENSG00000100302 ENSMUSG00000034472 UniProt Q96D21 P63032 RefSeq (mRNA) NM_014310 NM_001366725 NM_001376515 NM_001376516 NM_029182 RefSeq (protein) NP_055125 NP_001353654 NP_001363444 NP_001363445 NP_083458 Location (UCSC) Chr 22: 35.54 – 35.55 Mb Chr 8: 75.94 – 75.95 Mb PubMed search [3] [4]
Wikidata
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GTP-binding protein Rhes is a protein that in humans is encoded by the RASD2 gene.^[5][6][7][8]

This gene encodes a Ras-related protein that is produced largely in the striatum. The product of this gene binds to GTP and possesses intrinsic GTPase activity. The gene belongs to the Ras superfamily of small GTPases. The exact function of this gene is unknown, but most striatum-specific mRNAs characterized to date encode components of signal transduction cascades.^[8]