Protein-coding gene in the species Homo sapiens
RalBP1-associated Eps domain-containing protein 2 is a protein that in humans is encoded by the REPS2 gene.[5][6][7]
Function
The product of this gene is part of a protein complex that regulates the endocytosis of growth factor receptors. The encoded protein directly interacts with a GTPase activating protein that functions downstream of the small G protein Ral. Its expression can negatively affect receptor internalization and inhibit growth factor signaling. Multiple transcript variants encoding different isoforms have been found for this gene.[7]
Interactions
REPS2 has been shown to interact with EPN1,[8] EPS15[9] and RALBP1.[5]