Protein-coding gene in the species Homo sapiens
REV1 |
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Available structures |
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PDB | Ortholog search: PDBe RCSB |
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List of PDB id codes |
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2EBW, 2LSI, 2LSK, 2LSY, 3GQC, 3VU7, 4BA9, 4EXT, 4GK0, 4GK5, 2N1G |
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Identifiers |
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Aliases | REV1, REV1L, AIBP80, DNA directed polymerase, REV1 DNA directed polymerase |
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External IDs | OMIM: 606134 MGI: 1929074 HomoloGene: 32309 GeneCards: REV1 |
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Wikidata |
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DNA repair protein REV1 is a protein that in humans is encoded by the REV1 gene.[5][6]
This gene encodes a protein with similarity to the S. cerevisiae mutagenesis protein Rev1. The Rev1 proteins contain a BRCT domain, which is important in protein-protein interactions. A suggested role for the human Rev1-like protein is as a scaffold that recruits DNA polymerases involved in translesion synthesis (TLS) of damaged DNA. Two alternatively spliced transcript variants that encode different proteins have been found.[6]
Rev1 is a Y family DNA polymerase; it is sometimes referred to as a deoxycytidyl transferase because it only inserts deoxycytidine (dC) across from lesions. Whether G, A, T, C, or an abasic site, Rev1 will always add a C. Rev1 has the ability to always add a C, because it uses an arginine as a template which complements well with C.[7] Yet it is believed[by whom?] that Rev1 rarely uses its polymerase activity; rather it is thought that Rev1's primary role is as a protein landing pad, whereby it helps direct the recruitment of TLS proteins, especially Pol ζ (Rev3/Rev7).
Interactions
REV1 has been shown to interact with MAD2L2.[8] It is believed that Rev1 may interact with PCNA, once ubiquitylated due to a lesion, and help recruit Pol ζ (Rev3/Rev7) a B family polymerase involved in TLS.