RFX3
Identifiers
Aliases	RFX3, regulatory factor X3
External IDs	OMIM: 601337 MGI: 106582 HomoloGene: 7917 GeneCards: RFX3
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9p24.2 Start 3,218,297 bp[1] End 3,526,004 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19|19 C1 Start 27,739,121 bp[2] End 27,988,566 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in bronchial epithelial cell Brodmann area 23 middle temporal gyrus cerebellar vermis right uterine tube caput epididymis corpus callosum entorhinal cortex internal globus pallidus endothelial cell Top expressed in olfactory epithelium piriform cortex medial ganglionic eminence dentate gyrus Region I of hippocampus proper primitive streak olfactory tubercle nucleus accumbens ventromedial nucleus pituitary gland More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding sequence-specific DNA binding DNA-binding transcription factor activity RNA polymerase II cis-regulatory region sequence-specific DNA binding protein binding transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component transcription regulator complex nucleus extracellular region Biological process cell differentiation regulation of transcription, DNA-templated positive regulation of type B pancreatic cell development regulation of insulin secretion epithelial cilium movement involved in determination of left/right asymmetry cell maturation transcription, DNA-templated positive regulation of transcription, DNA-templated multicellular organism development type B pancreatic cell maturation determination of left/right symmetry negative regulation of transcription, DNA-templated cilium-dependent cell motility endocrine pancreas development positive regulation of transcription by RNA polymerase II type B pancreatic cell differentiation cilium assembly regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5991 19726 Ensembl ENSG00000080298 ENSMUSG00000040929 UniProt P48380 P48381 RefSeq (mRNA) NM_001282116 NM_001282117 NM_002919 NM_134428 NM_001377999 NM_001166414 NM_011265 NM_001360357 NM_001360358 RefSeq (protein) NP_001269045 NP_001269046 NP_002910 NP_602304 NP_001364928 NP_001159886 NP_035395 NP_001347286 NP_001347287 Location (UCSC) Chr 9: 3.22 – 3.53 Mb Chr 19: 27.74 – 27.99 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Transcription factor RFX3 is a protein that in humans is encoded by the RFX3 gene.^[5][6]

This gene is a member of the regulatory factor X gene family, which encodes transcription factors that contain a highly-conserved winged helix DNA binding domain. The protein encoded by this gene is structurally related to regulatory factors X1, X2, X4, and X5. It is a transcriptional activator that can bind DNA as a monomer or as a heterodimer with other RFX family members. Two transcript variants encoding different isoforms have been described for this gene, and at least one of the variants utilizes alternative polyadenylation signals.^[6]