RGS8

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2IHD, 2ODE, 5DO9

Identifiers

Aliases

RGS8, regulator of G protein signaling 8

External IDs

OMIM: 607189 MGI: 108408 HomoloGene: 23152 GeneCards: RGS8

Gene location (Human)

Chr.	Chromosome 1 (human)^[1]

Band	1q25.3	Start	182,641,816 bp^[1]
Band	1q25.3	End	182,684,587 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 1 (mouse)^[2]

Band	1 G3\|1 65.41 cM	Start	153,528,771 bp^[2]
Band	1 G3\|1 65.41 cM	End	153,576,069 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

nucleus accumbens

pons

putamen

caudate nucleus

cerebellar vermis

sperm

hypothalamus

prefrontal cortex

external globus pallidus

Brodmann area 46

Top expressed in

cerebellar vermis

medial geniculate nucleus

medial dorsal nucleus

superior colliculus

lateral geniculate nucleus

olfactory tubercle

inferior colliculus

superior frontal gyrus

nucleus accumbens

globus pallidus

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	protein binding GTPase activator activity GTPase activity
Cellular component	cytoplasm extrinsic component of cytoplasmic side of plasma membrane neuronal cell body membrane perikaryon plasma membrane dendrite cell projection membrane nucleus
Biological process	G protein-coupled acetylcholine receptor signaling pathway regulation of dopamine receptor signaling pathway positive regulation of GTPase activity negative regulation of signal transduction G protein-coupled receptor signaling pathway
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


85397


67792

Ensembl


ENSG00000135824


ENSMUSG00000042671

UniProt


P57771


Q8BXT1

RefSeq (mRNA)

NM_001102450 NM_033345 NM_001369564 NM_001387847 NM_001387848
NM_001387849


NM_026380 NM_001347115 NM_001357525

RefSeq (protein)


NP_001095920 NP_203131 NP_001356493


NP_001334044 NP_080656 NP_001344454

Location (UCSC)

Chr 1: 182.64 – 182.68 Mb

Chr 1: 153.53 – 153.58 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Regulator of G-protein signaling 8 is a protein that in humans is encoded by the RGS8 gene.^[5]^[6]

This gene is a member of the regulator of G protein signaling (RGS) family and encodes a protein with a single RGS domain. Regulator of G protein signaling (RGS) proteins are regulatory and structural components of G protein-coupled receptor complexes. They accelerate transit through the cycle of GTP binding and hydrolysis to GDP, thereby terminating signal transduction, but paradoxically, also accelerate receptor-stimulated activation.^[6]

References

Berman DM, Wilkie TM, Gilman AG (1996). "GAIP and RGS4 are GTPase-activating proteins for the Gi subfamily of G protein alpha subunits". Cell. 86 (3): 445–452. doi:10.1016/S0092-8674(00)80117-8. PMID 8756726. S2CID 12427406.
Harrington JJ, Sherf B, Rundlett S, et al. (2001). "Creation of genome-wide protein expression libraries using random activation of gene expression". Nat. Biotechnol. 19 (5): 440–5. doi:10.1038/88107. PMID 11329013. S2CID 25064683.
Luo X, Popov S, Bera AK, Wilkie TM, Muallem S (2001). "RGS proteins provide biochemical control of agonist-evoked [Ca2+]i oscillations". Molecular Cell. 7 (3): 651–660. doi:10.1016/S1097-2765(01)00211-8. PMID 11463389.
Pashkov V, Huang J, Parameswara VK, Kedzierski W, Kurrasch DM, Tall GG, Esser V, Gerard RD, Uyeda K, Towle HC, Wilkie TM (2011). "Regulator of G protein signaling (RGS16) inhibits hepatic fatty acid oxidation in a carbohydrate response element-binding protein (ChREBP)-dependent manner". J Biol Chem. 286 (17): 15116–15125. doi:10.1074/jbc.M110.216234. PMC 3083217. PMID 21357625.
Popov S, Yu K, Kozasa T, Wilkie TM (1997). "The regulators of G protein signaling (RGS) domains of RGS4, RGS10 and GAIP retain GTPase activating protein activity in vitro". Proc Natl Acad Sci USA. 94 (14): 7216–20. Bibcode:1997PNAS...94.7216P. doi:10.1073/pnas.94.14.7216. PMC 23796. PMID 9207071.
Popov SG, Krishna UM, Falck JR, Wilkie TM (2000). "Ca2+/Calmodulin reverses phosphatidylinositol 3,4, 5-trisphosphate-dependent inhibition of regulators of G protein-signaling GTPase-activating protein activity". J Biol Chem. 275 (25): 18962–8. doi:10.1074/jbc.M001128200. PMID 10747990.
Ross EM, Wilkie TM (2000). "GTPase-activating proteins for heterotrimeric G proteins: regulators of G protein signaling (RGS) and RGS-like proteins". Annual Review of Biochemistry. 69: 795–827. doi:10.1146/annurev.biochem.69.1.795. PMID 10966476.
Saitoh O, Murata Y, Odagiri M, et al. (2002). "Alternative splicing of RGS8 gene determines inhibitory function of receptor type-specific Gq signaling". Proc. Natl. Acad. Sci. U.S.A. 99 (15): 10138–43. Bibcode:2002PNAS...9910138S. doi:10.1073/pnas.152085999. PMC 126637. PMID 12110731.
Sierra DA, Gilbert DJ, Householder D, Grishin NV, Yu K, Ukidwe P, Barker SA, He W, Wensel TG, Otero G, Brown G, Copeland NG, Jenkins NA, Wilkie TM (2002). "Evolution of the regulators of G-protein signaling multigene family in mouse and human". Genomics. 79 (2): 177–85. doi:10.1006/geno.2002.6693. PMID 11829488. S2CID 16065132.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Masuho I, Itoh M, Itoh H, Saitoh O (2004). "The mechanism of membrane-translocation of regulator of G-protein signaling (RGS) 8 induced by Galpha expression". J. Neurochem. 88 (1): 161–8. doi:10.1046/j.1471-4159.2003.02139.x. PMID 14675160.
Larminie C, Murdock P, Walhin JP, et al. (2004). "Selective expression of regulators of G-protein signaling (RGS) in the human central nervous system". Brain Res. Mol. Brain Res. 122 (1): 24–34. doi:10.1016/j.molbrainres.2003.11.014. PMID 14992813.
Saitoh O, Yoshihiro K (2005). "Biochemical and Electrophysiological Analyses of RGS8 Function". Regulators of G-Protein Signaling, Part B. Methods in Enzymology. Vol. 390. pp. 129–48. doi:10.1016/S0076-6879(04)90009-2. ISBN 9780121827953. PMID 15488175. ((cite book)): |journal= ignored (help)
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Benians A, Nobles M, Tinker A (2005). "Participation of RGS8 in the ternary complex of agonist, receptor and G-protein". Biochem. Soc. Trans. 32 (Pt 6): 1045–7. doi:10.1042/BST0321045. PMID 15506959.
Benians A, Nobles M, Hosny S, Tinker A (2005). "Regulators of G-protein signaling form a quaternary complex with the agonist, receptor, and G-protein. A novel explanation for the acceleration of signaling activation kinetics". J. Biol. Chem. 280 (14): 13383–94. doi:10.1074/jbc.M410163200. PMID 15677457.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
Villasenor A, Wang ZV, Rivera LB, Ocal O, Asterholm IW, Scherer PE, Brekken RA, Cleaver O, Wilkie TM (2010). "Rgs16 and Rgs8 in embryonic endocrine pancreas and mouse models of diabetes". Disease Models & Mechanisms. 3 (9–10): 567–580. doi:10.1242/dmm.003210. PMC 2931535. PMID 20616094.
Wilkie TM, Kinch L (2005). "New roles for Galpha and RGS proteins: communication continues despite pulling sisters apart". Current Biology. 15 (20): R843-54. doi:10.1016/j.cub.2005.10.008. PMID 16243026. S2CID 18174795.

v t e PDB gallery
2ihd: Crystal structure of Human Regulator of G-protein signaling 8, RGS8 2ode: Crystal structure of the heterodimeric complex of human RGS8 and activated Gi alpha 3

References

Further reading