Protein-coding gene in the species Homo sapiens
Rhomboid family member 2 is a protein that in humans is encoded by the RHBDF2 gene.[5][6] The alternative name iRhom2 has been proposed, in order to clarify that it is a catalytically inactive member of the rhomboid family of intramembrane serine proteases.[7][8]
The RHBDF2 gene is located on the long arm of chromosome 17 (17q25.1) on the Crick (minus) strand. It is 30.534 kilobases in length and encodes a protein of 856 amino acids with a predicted molecular weight of 96.686 kilodaltons.
The RHBDF2 protein plays an important role in the secretion of tumor necrosis factor alpha,[9][10][11] and has also been implicated in familial esophageal cancer.[12]
It is involved in the regulation of the secretion of several ligands of the epidermal growth factor receptor.[13]