RHCG
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3HD6
Identifiers
Aliases	RHCG, C15orf6, PDRC2, RHGK, SLC42A3, Rh family C glycoprotein
External IDs	OMIM: 605381 MGI: 1888517 HomoloGene: 32310 GeneCards: RHCG
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q26.1 Start 89,471,398 bp[1] End 89,496,589 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 D2|7 45.09 cM Start 79,243,111 bp[2] End 79,267,405 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cavity of mouth body of tongue cervix epithelium gums human penis periodontal fiber thymus superior surface of tongue vagina kidney Top expressed in kidney spermatocyte spermatid seminiferous tubule renal pelvis medullary collecting duct renal calyx adrenal gland morula olfactory bulb More reference expression data BioGPS More reference expression data
Gene ontology Molecular function ankyrin binding ammonium transmembrane transporter activity identical protein binding Cellular component integral component of membrane membrane plasma membrane integral component of plasma membrane basolateral plasma membrane apical plasma membrane extracellular exosome cytoplasmic vesicle Biological process ammonium transmembrane transport epithelial cell differentiation amine transport organic cation transport transepithelial ammonium transport cellular ion homeostasis regulation of pH homeostatic process transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51458 56315 Ensembl ENSG00000140519 ENSMUSG00000030549 UniProt Q9UBD6 Q9QXP0 RefSeq (mRNA) NM_016321 NM_001321041 NM_019799 RefSeq (protein) NP_001307970 NP_057405 NP_062773 Location (UCSC) Chr 15: 89.47 – 89.5 Mb Chr 7: 79.24 – 79.27 Mb PubMed search [3] [4]
Wikidata
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Rh family, C glycoprotein, also known as RHCG, is a protein that in humans is encoded by the RHCG gene.^[5][6]

Function

RHCG plays a critical role in ammonium handling and pH homeostasis in the kidney.^[7] The structure of the RHCG protein^[8] indicates that it has a hydrophobic ammonia-conducting channel and shows that it shares a common fold with the ammonia transporters, thus making it an ammonia transporter.