RIC8A
Identifiers
AliasesRIC8A, RIC8, RIC8 guanine nucleotide exchange factor A
External IDsOMIM: 609146 MGI: 2141866 HomoloGene: 23331 GeneCards: RIC8A
Orthologs
SpeciesHumanMouse
Entrez

60626

101489

Ensembl

ENSG00000177963

ENSMUSG00000025485

UniProt

Q9NPQ8

Q3TIR3

RefSeq (mRNA)

NM_001286134
NM_021932
NM_001386941
NM_001386942

NM_053194

RefSeq (protein)

NP_001273063
NP_068751

NP_444424

Location (UCSC)Chr 11: 0.21 – 0.22 MbChr 7: 140.44 – 140.44 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Resistance to inhibitors of cholinesterase-8A (Ric-8A), also known as Synembryn-A, is a protein that in humans is encoded by the RIC8A gene.[5][6][7]

Interactions

RIC8A has been shown to interact with GNAO1,[8] GNA13,[9][8] GNAQ,[8][10] GNAS complex locus,[10] GNAI2,[8] GNAI1[8] and GNAI3.[8]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000177963 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025485 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Miller KG, Emerson MD, McManus JR, Rand JB (Sep 2000). "RIC-8 (Synembryn): a novel conserved protein that is required for G(q)alpha signaling in the C. elegans nervous system". Neuron. 27 (2): 289–99. doi:10.1016/S0896-6273(00)00037-4. PMC 4704990. PMID 10985349.
  6. ^ Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
  7. ^ "Entrez Gene: RIC8A resistance to inhibitors of cholinesterase 8 homolog A (C. elegans)".
  8. ^ a b c d e f Tall, Gregory G; Krumins Andrejs M; Gilman Alfred G (Mar 2003). "Mammalian Ric-8A (synembryn) is a heterotrimeric Galpha protein guanine nucleotide exchange factor". J. Biol. Chem. United States. 278 (10): 8356–62. doi:10.1074/jbc.M211862200. ISSN 0021-9258. PMID 12509430.
  9. ^ Wang L, Guo D, Xing B, Zhang JJ, Shu HB, Guo L, Huang XY (September 2011). "Resistance to inhibitors of cholinesterase-8A (Ric-8A) is critical for growth factor receptor-induced actin cytoskeletal reorganization". The Journal of Biological Chemistry. 286 (35): 31055–61. doi:10.1074/jbc.M111.253427. PMC 3162464. PMID 21771786.
  10. ^ a b Klattenhoff, Carla; Montecino Martín; Soto Ximena; Guzmán Leonardo; Romo Ximena; García María Angeles; Mellstrom Britt; Naranjo José Ramón; Hinrichs María Victoria; Olate Juan (May 2003). "Human brain synembryn interacts with Gsalpha and Gqalpha and is translocated to the plasma membrane in response to isoproterenol and carbachol". J. Cell. Physiol. United States. 195 (2): 151–7. doi:10.1002/jcp.10300. hdl:10533/174200. ISSN 0021-9541. PMID 12652642. S2CID 84975473.

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