RNASE1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1DZA, 1E21, 1H8X, 1Z7X, 2E0J, 2E0L, 2E0M, 2E0O, 2K11, 2Q4G, 3F8G, 4KXH
Identifiers
Aliases	RNASE1, RAC1, RIB1, RNS1, ribonuclease A family member 1, pancreatic
External IDs	OMIM: 180440 MGI: 97919 HomoloGene: 7919 GeneCards: RNASE1
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q11.2 Start 20,801,228 bp[1] End 20,802,855 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14 C1|14 26.4 cM Start 51,382,455 bp[2] End 51,384,242 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lung upper lobe of left lung synovial joint gallbladder body of pancreas synovial membrane gastric mucosa right coronary artery inferior ganglion of vagus nerve corpus callosum Top expressed in pyloric antrum islet of Langerhans parotid gland crypt of lieberkuhn of small intestine epithelium of stomach stria vascularis esophagus duodenum mucous cell of stomach jejunum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nuclease activity protein binding hydrolase activity ribonuclease A activity nucleic acid binding endonuclease activity ribonuclease activity lyase activity Cellular component extracellular region extracellular exosome Biological process RNA phosphodiester bond hydrolysis, endonucleolytic defense response to virus RNA phosphodiester bond hydrolysis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6035 19752 Ensembl ENSG00000129538 ENSMUSG00000035896 UniProt P07998 P00683 Q8C6G3 RefSeq (mRNA) NM_198235 NM_002933 NM_198232 NM_198234 NM_011271 RefSeq (protein) NP_002924 NP_937875 NP_937877 NP_937878 NP_035401 Location (UCSC) Chr 14: 20.8 – 20.8 Mb Chr 14: 51.38 – 51.38 Mb PubMed search [3] [4]
Wikidata
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Ribonuclease pancreatic is an enzyme that in humans is encoded by the RNASE1 gene.^[5][6]

Function

This gene encodes a member of the pancreatic-type of secretory ribonucleases, a subset of the ribonuclease A super-family. The encoded endonuclease cleaves internal phosphodiester RNA bonds on the 3'-side of pyrimidine bases. It prefers poly(C) as a substrate and hydrolyses 2',3'-cyclic nucleotides, with a pH optimum near 8.0. The encoded protein is monomeric and more commonly acts to degrade ss-RNA over ds-RNA. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified.^[6]