RRAD
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesRRAD, RAD, RAD1, REM3, Ras related glycolysis inhibitor and calcium channel regulator
External IDsOMIM: 179503 MGI: 1930943 HomoloGene: 3071 GeneCards: RRAD
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004165
NM_001128850

NM_019662

RefSeq (protein)

NP_001122322
NP_004156

n/a

Location (UCSC)Chr 16: 66.92 – 66.93 MbChr 8: 105.35 – 105.36 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Ras Related Glycolysis Inhibitor and Calcium Channel Regulator (RRAD) is a protein that in humans is encoded by the RRAD gene.[5][6] RRAD is a Ras-related small GTPase that is regulated by p53 and plays a role in the regulation of aerobic glycolysis.[7]

Interactions

RRAD has been shown to interact with CAMK2G[8] and TPM2.[9]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000166592 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031880 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Doria A, Caldwell JS, Ji L, Reynet C, Rich SS, Weremowicz S, Morton CC, Warram JH, Kahn CR, Krolewski AS (March 1995). "Trinucleotide repeats at the rad locus. Allele distributions in NIDDM and mapping to a 3-cM region on chromosome 16q". Diabetes. 44 (2): 243–7. doi:10.2337/diabetes.44.2.243. PMID 7859947.
  6. ^ "Entrez Gene: RRAD Ras-related associated with diabetes".
  7. ^ Zhang, Cen (2014). "Tumor suppressor p53 negatively regulates glycolysis stimulated by hypoxia through its target RRAD". Oncotarget. 4 (14): 5535–5546. doi:10.18632/oncotarget.2137. PMC 4170611. PMID 25114038.
  8. ^ Moyers JS, Bilan PJ, Zhu J, Kahn CR (May 1997). "Rad and Rad-related GTPases interact with calmodulin and calmodulin-dependent protein kinase II". J. Biol. Chem. 272 (18): 11832–9. doi:10.1074/jbc.272.18.11832. PMID 9115241.
  9. ^ Zhu J, Bilan PJ, Moyers JS, Antonetti DA, Kahn CR (January 1996). "Rad, a novel Ras-related GTPase, interacts with skeletal muscle beta-tropomyosin". J. Biol. Chem. 271 (2): 768–73. doi:10.1074/jbc.271.2.768. PMID 8557685.

Further reading