CAS Number
PubChem CID
CompTox Dashboard (EPA)
Chemical and physical data
Molar mass200.285 g·mol−1
3D model (JSmol)
  • c13c(C2)cccc1[nH]cc3CC2N(C)C
  • InChI=1S/C13H16N2/c1-15(2)11-6-9-4-3-5-12-13(9)10(7-11)8-14-12/h3-5,8,11,14H,6-7H2,1-2H3

RU-28306 is a tricyclic tryptamine derivative which acts as a serotonin receptor agonist, with selectivity for 5-HT1 and 5-HT2 subtypes. It can be regarded either as a conformationally constrained derivative of DMT, or a structurally simplified analogue of LSD, but the binding affinity of racemic RU-28306 is closer to that of DMT, though with relatively higher affinity for 5-HT2 subtypes and lower for 5-HT1.[1] It has been sold as a designer drug and was first reported to the EMCDDA by a forensic laboratory in Slovenia in 2017.[2]

See also


  1. ^ Taylor EW, Nikam S, Weck B, Martin A, Nelson D (October 1987). "Relative selectivity of some conformationally constrained tryptamine analogs at 5-HT1, 5-HT1A and 5-HT2 recognition sites". Life Sciences. 41 (16): 1961–9. doi:10.1016/0024-3205(87)90749-1. PMID 3657392.
  2. ^ EMCDDA – Europol 2017 Annual Report on the implementation of Council Decision 2005/387/JHA