When Ray Kaukonde, ZANU-PF MP for Mudzi East, was made Provincial Governor of Mashonaland East, he obtained an ex officio seat in Parliament and therefore vacated his constituency of Mudzi East. A byelection was held on 18 June 2005 at which the electorate was 42,072. Joseph Musa (ZANU-PF) won with 15,811 votes; Bvunzayi Gozi (MDC) had 2,382 votes.
There was a byelection in Gutu North following the death of Josiah Tungamirai (ZANU-PF) on 26 August 2005. The election was held on 26 November 2005 and resulted in the election of Lovemore Matuke (ZANU PF) with 20,712 votes against Crispa Zvovuno Musoni (MDC) who obtained 4,786 votes.
A byelection was held in Budiriro following the death of Gilbert Shoko (MDC) on 23 February 2006. Polling day was 20 May 2006. This election saw the first contest between the rival factions of the MDC, and was easily won by the Tsvangirai faction. Emmanuel Chisvuure (MDC – Tsvangirai) won 7,949 votes to 3,961 for Jeremiah Bvirindi (ZANU PF). Gabriel Chaibva (MDC – Mutambara) won only 504.
Dr Tichaona Joseph Benjamin Jokonya, ZANU-PF member for Chikomba and Minister of Information and Publicity, died on 24 June 2006. At the byelection in the constituency on 7 October 2006, Steven Chiurayi (ZANU-PF) polled 11,247 votes, while Amos Jiri (MDC – Tsvangirai) polled 4,243.
Sandra Machirori, ZANU-PF member for Rushinga, died on 1 July 2006. The byelection to replace her was held on 7 October, in which Lazarus Dokora (ZANU-PF) won with 13,642 votes against 1,801 votes for Kudakwashe Chideya (MDC – Tsvangirai). The electorate was 39,650.
Aaron Babyi, ZANU-PF member for Chiredzi South, died on 15 September 2006. A byelection there on 17 February 2007 saw Kallisto Gwanetsa (ZANU-PF) hold the seat with 10,401 votes, Mrs Emmaculate Makondo (MDC – Tsvangirai) getting 3,300, Mayithani Chauke (UPP) 896, and Nehemiah Zenamwe (MDC – Mutambara) 674. There were 332 spoilt ballots and the electorate was 53,128.
A byelection was held in Zaka East following the death of Tinos Rusere (ZANU-PF) on 2 March 2007. Polling day was fixed for 9 June; both factions of the MDC boycotted the election. Col. Livingstone Chineka (ZANU-PF) won the seat with 11,152 votes; Nicholas Shanga (United People's Party) was runner up with 1,117 votes, and Lameck Batirai (Zimbabwe People's Democratic Party) had 622 votes. There was a 27.1% turnout.