| Reticulate acropigmentation of Kitamura | |
|---|---|
| Other names | RAK[1] |
| Specialty | Dermatology |
| Symptoms | Coloured freckle-like and slightly depressed flat spots arranged in a lace-like pattern[2] |
| Usual onset | Teenagers and early adulthood[2] |
| Differential diagnosis | Dowling–Degos disease[2] |
| Frequency | Rare[1] |
Reticulate acropigmentation of Kitamura is a type of pigmentation disorder of the skin.[2] It presents with coloured freckle-like and slightly depressed flat spots arranged in a lace-like pattern on the backs of hands and feet.[2] It tends to occur in skin folds of teenagers and in early adulthood, and darkens over time.[2]
It is inherited in an autosomal-dominant fashion.[2]
The condition is rare.[1] It was first described in Japan, before recognising that is also occurs elsewhere.[2]
This condition is associated with mutations in the a disintegrin and metalloproteinase domain-containing protein 10 (ADAM10) gene. This association was first shown in 2013.[citation needed]