RBL1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1H28, 4YOO, 4YOS, 4YOZ
Identifiers
Aliases	RBL1, CP107, PRB1, p107, retinoblastoma-like 1, RB transcriptional corepressor like 1
External IDs	OMIM: 116957 MGI: 103300 HomoloGene: 2172 GeneCards: RBL1
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20q11.23 Start 36,996,349 bp[1] End 37,095,997 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2 H1|2 78.05 cM Start 156,987,813 bp[2] End 157,046,454 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon ganglionic eminence bone marrow cells corpus callosum thymus lymph node stromal cell of endometrium gastrocnemius muscle appendix sural nerve Top expressed in Paneth cell hair follicle medial ganglionic eminence dermis spermatocyte vas deferens renal corpuscle abdominal wall thymus atrioventricular valve More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transcription factor binding protein binding promoter-specific chromatin binding DNA-binding transcription repressor activity, RNA polymerase II-specific Cellular component nucleus transcription regulator complex nucleoplasm chromatin Biological process regulation of cell cycle regulation of transcription by RNA polymerase II cell cycle viral process regulation of transcription, DNA-templated negative regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II regulation of lipid kinase activity negative regulation of gene expression transcription, DNA-templated negative regulation of cellular senescence chromatin organization regulation of mitotic cell cycle cell differentiation regulation of cell division negative regulation of G1/S transition of mitotic cell cycle Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5933 19650 Ensembl ENSG00000080839 ENSMUSG00000027641 UniProt P28749 Q64701 RefSeq (mRNA) NM_002895 NM_183404 NM_001323281 NM_001323282 NM_001139516 NM_011249 RefSeq (protein) NP_001310210 NP_001310211 NP_002886 NP_899662 NP_001132988 NP_035379 Location (UCSC) Chr 20: 37 – 37.1 Mb Chr 2: 156.99 – 157.05 Mb PubMed search [3] [4]
Wikidata
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Retinoblastoma-like 1 (p107), also known as RBL1, is a protein that in humans is encoded by the RBL1 gene.^[5][6]

Function

The protein encoded by this gene is similar in sequence and possibly function to the product of the retinoblastoma 1 (RB1) gene. The RB1 gene product is a tumor suppressor protein that appears to be involved in cell cycle regulation, as it is phosphorylated in the S to M phase transition and is dephosphorylated in the G1 phase of the cell cycle. Both the RB1 protein and the product of this gene can form a complex with adenovirus E1A protein and SV40 Large T-antigen, with the SV40 large T-antigen binding only to the unphosphorylated form of each protein. In addition, both proteins can inhibit the transcription of cell cycle genes containing E2F binding sites in their promoters. Due to the sequence and biochemical similarities with the RB1 protein, it is thought that the protein encoded by this gene may also be a tumor suppressor. Two transcript variants encoding different isoforms have been found for this gene.^[5]

Interactions

Retinoblastoma-like protein 1 has been shown to interact with: