The Rexed laminae comprise a system of ten layers of grey matter (I–X), identified in the early 1950s by Bror Rexed to label portions of the grey columns of the spinal cord.^[1]^[2]

Similar to Brodmann areas, they are defined by their cellular structure rather than by their location, but the location still remains reasonably consistent^{[citation needed]}.

Laminae

Posterior grey column: I–VI
- Lamina I: marginal nucleus of spinal cord or posteromarginal nucleus^[3]
- Lamina II: substantia gelatinosa of Rolando^[3]
- Laminae III and IV: nucleus proprius^[3]
- Lamina V: Neck of the dorsal horn. Neurons within lamina V are mainly involved in processing sensory afferent stimuli from cutaneous, muscle and joint mechanical nociceptors as well as visceral nociceptors. This layer is home to wide dynamic range tract neurons, interneurons and propriospinal neurons. Viscerosomatic pain signal convergence often occurs in this lamina due to the presence of wide dynamic range tract neurons resulting in pain referral.^[4]
- Lamina VI: Base of the dorsal horn. No nociceptive input occurs here, instead this lamina receives input from large-diameter fibres innervating muscles and joints and from muscle spindles which are sensitive to innocuous joint movement and muscle stretch to feed forward this information to the cerebellum where it can modulate muscle tone accordingly.^[5]
Lateral grey column: VII and X
- Lamina VII: intermediomedial nucleus, intermediolateral nucleus, posterior thoracic nucleus in the thoracic and upper lumbar region^[6]
- Lamina X: an area of grey matter surrounding the central canal.^[6]^[3]
Anterior grey column: VIII–IX
- Lamina VIII: motor interneurons; Commissural nucleus^[6]
- Lamina IX: hypaxial (body wall muscles), lateral (in limb regions) and medial (back muscles) motor neurons, also phrenic and spinal accessory nuclei at cervical levels, and Onuf's nucleus in the sacral region

References

^ Rexed B (June 1952). "The cytoarchitectonic organization of the spinal cord in the cat". The Journal of Comparative Neurology. 96 (3): 414–95. doi:10.1002/cne.900960303. PMID 14946260. S2CID 42584106.
^ Rexed B (April 1954). "A cytoarchitectonic atlas of the spinal cord in the cat". The Journal of Comparative Neurology. 100 (2): 297–379. doi:10.1002/cne.901000205. PMID 13163236. S2CID 40517545.
^ ^a ^b ^c ^d Carpenter, Malcolm B. (1985). Core text of neuroanatomy (3rd. ed.). Baltimore: Williams & Wilkins. pp. 61–68. ISBN 0683014552.
^ Darby SA, Cramer GD (2013). Clinical Anatomy of the Spine, Spinal Cord and ANS. Saint Louis, MO, USA: Mosby. pp. 341–413. ISBN 978-0323079549.
^ Kandel ER, Schwartz JH (2013). Principles of Neural Science (5th ed.). New York City, NY, USA: McGraw-Hill Group. p. 535. ISBN 978-0-07-139011-8.
^ ^a ^b ^c Blumenfeld H (2010). "Neuroanatomy through Clinical Cases". Sunderland, MA: Sinauer Associates. ((cite journal)): Cite journal requires |journal= (help)

Spinal cord

General features

Grey columns

Posterior grey column	Marginal nucleus Substantia gelatinosa of Rolando Nucleus proprius Rexed lamina V Rexed lamina VI
Lateral grey column	Intermediolateral nucleus Posterior thoracic nucleus
Anterior grey column	Interneuron Alpha motor neuron Onuf's nucleus Gamma motor neuron
Other	Rexed laminae Central gelatinous substance Gray commissure

White matter

Sensory

Posterior	Posterior column-medial lemniscus pathway Gracile Cuneate
Lateral	Spinocerebellar dorsal ventral Spinothalamic lateral anterior Posterolateral Spinotectal
Anterior	Spinoreticular tract Spino-olivary tract

Motor

Lateral	Corticospinal Lateral Extrapyramidal Rubrospinal Raphespinal Reticulospinal Hypothalamospinal
Anterior	Corticospinal Anterior Extrapyramidal Vestibulospinal Reticulospinal Tectospinal Raphespinal Olivospinal

Both

Anterior white commissure

External features

Ventral
- Anterior median fissure
- Anterolateral sulcus
Dorsal
- Posterior median sulcus
- Posterolateral sulcus