Rifampicin/isoniazid/pyrazinamide, also known as rifampin/isoniazid/pyrazinamide, and sold under the trade name Rifater, is a medication used to treat tuberculosis.^[1] It is a fixed dose combination of rifampicin, isoniazid, and pyrazinamide.^[1] It is used either by itself or along with other antituberculosis medication.^[1] It is taken by mouth.^[1]

Side effects are those of the underlying medications.^[1] These may include poor coordination, loss of appetite, nausea, joint pain, feeling tired, and numbness.^[2] Severe side effects include liver problems.^[3] Use in those under the age of 15 may not be appropriate.^[3] It is unclear if use in pregnancy is safe for the baby.^[3]

Rifampicin/isoniazid/pyrazinamide was approved for medical use in the United States in 1994.^[3] It is on the World Health Organization's List of Essential Medicines.^[4]

Medical uses

The hope of a fixed-dose combination pill is to increase the likelihood that people will take all of three medications.^[5] Also, if people forget to take one or two of their drugs, they might not then develop resistance to the remaining drugs.^{[citation needed]}

Society and culture

It is manufactured by Aventis.^{[citation needed]}