Ruben is the surname of:

• Aaron Ruben (1914–2010), American television director and producer
• Adam Ruben, American writer, comedian, rapper, storyteller, science communicator and molecular biologist
• Alessandro Ruben (born 1966), Italian politician
• Carlos Rubén (born 1983), Spanish footballer
• J. Walter Ruben (1899–1942), American screenwriter, film director and producer
• Joseph Ruben (born 1950), American retired filmmaker
• Josh Ruben (born 1983), American actor, comedian, film director and producer
• Livingston Antony Ruben, aka Ruben (film editor), Indian film editor
• Marco Ruben (born 1986), Argentine former footballer
• Sam Ruben (1913–1943), American chemist
• Samuel Ruben (1900–1988), American inventor
• Walter Ruben (Indologist) (1899–1982), German Indologist