Interior comic work includes:

• Challengers of the Unknown vol. 3 #15: "Earth Came A-Walkin" (with Steven Grant, DC Comics, 1998)
• Tales of the Green Lantern: "Know Evil" (with John Ostrander, one-shot, DC Tangent, 1998)
• Buffy the Vampire Slayer (Dark Horse):
  • Spike & Dru #1-2 (with Christopher Golden and James Marsters, 1999)
  • Buffy Annual '99: "Bad Dog" (with Doug Petrie, co-feature, 1999)
  • TV Guide Nov. 20-26: "Angel: Point of Order" (with David Fury, News America Publications, 1999)
  • Ring of Fire (with Doug Petrie, graphic novel, 2000)
  • Reunion (with Jane Espenson, one-shot, 2002)
• Dark Horse Presents (anthology, Dark Horse):
  • "The Bookroom Horror" (with Mike Mignola, in #142, 1999)
  • "Ragnok" (with John Arcudi, in #147-149, 1999)
  • "Witch's Son" (with Scott Allie, in #156-157, 2000)
• Young Justice 80-Page Giant #1: "Nosferatu to You Too" (with Chuck Dixon, anthology, DC Comics, 1999)
• Superman: The Man of Tomorrow #15: "Day of Judgement: Heart of Hell" (with J. M. DeMatteis, DC Comics, 1999)
• Hellboy: Box Full of Evil: "Killer in My Skull" (inks on Matt Smith, written by Mike Mignola, one-shot, Maverick, 1999)
• Flinch #12: "Tin God" (with John Arcudi, anthology, Vertigo, 2000)
• The Spectre vol. 4 #1-4, 6, 8–9, 11-13 (with J. M. DeMatteis, DC Comics, 2001–2002)
• Dark Horse Extra #42-44: "B.P.R.D." (with Christopher Golden, Dark Horse, 2001–2002)
• B.P.R.D.: Hollow Earth #1-3 (with Mike Mignola, Christopher Golden and Tom Sniegoski, Dark Horse, 2002)
• Batman: Gotham Knights #41: "I'll Be Watching" (with Ed Brubaker, co-feature, DC Comics, 2003)
• Métal Hurlant #6: "3 on a Match" (with Robert Alan Jones, anthology, Les Humanoïdes Associés, 2003)
• Arkham Asylum: Living Hell #1-6 (with Dan Slott, DC Comics, 2003)
• Hawkman vol. 4 #28-31, 34 (with Justin Gray and Jimmy Palmiotti, DC Comics, 2004–2005)
• Spider-Man Unlimited vol. 3 #8: "Everything" (with Joshua Ortega, anthology, Marvel, 2005)
• Seven Soldiers: Zatanna #1-4 (with Grant Morrison, DC Comics, 2005)
• X-Factor vol. 3 #1-4 (with Peter David, Marvel, 2006)
• The Goon: Noir #1: "Big Ma's Hootenanny & Slack-Jaw Fighting" (with Steve Niles, anthology, Dark Horse, 2006)
• The Ultimates 2 Annual #2 (flashback sequences, with Charlie Huston and Mike Deodato, Jr., Marvel, 2006)
• Worldstorm #2: "Savant" (with Christos Gage, anthology, Wildstorm, 2007)
• DC Infinite Halloween Special: "The Speed of Life" (with Mark Waid, anthology one-shot, DC Comics, 2007)
• Countdown to Final Crisis #2: "The Origin of Darkseid" (with Scott Beatty, co-feature, DC Comics, 2008)
• First Born: Aftermath: "Crisis of Faith" (with Ron Marz, anthology one-shot, Top Cow, 2008)
• Final Crisis: Resist (with Greg Rucka and Marco Rudy, one-shot, DC Comics, 2008)
• The Darkness #75: "Absolute Darkness" (with Phil Hester, among other artists, Top Cow, 2009)
• Wednesday Comics #1-12: "Kamandi, the Last Boy on Earth!" (with Dave Gibbons, anthology, DC Comics, 2009)
• Batman: The Return of Bruce Wayne #5: "Masquerade" (with Grant Morrison and Pere Pérez, DC Comics, 2010)
• The Atom and Hawkman #46: "Bye Bye Birdie!" (with Geoff Johns, DC Comics, 2010)
• Action Comics (DC Comics):
  • "Life Support" (with Damon Lindelof, co-feature in #900, 2011)
  • "Anchiale" (with Max Landis, co-feature in vol. 2 Annual #1, 2012)
  • "The Oz Effect, Part 2" (with Dan Jurgens, in #988, 2017)
  • "Invisible Mafia, Parts 4-6" (with Brian Michael Bendis, in #1004-1006, 2018–2019)
• Rocketeer Adventures #3: "A Rocketeer Story" (script and art, anthology, IDW Publishing, 2011)
• Artifacts #10: "Origin: Glacier Stone" (with Ron Marz and Tom Feister, co-feature, Top Cow, 2011)
• T.H.U.N.D.E.R. Agents vol. 3 #5: "Never the Whole Truth" (with Nick Spencer and CAFU, DC Comics, 2011)
• Jonah Hex vol. 2 #70: "Weird Western" (with Justin Gray, Jimmy Palmiotti and Diego Olmos, DC Comics, 2011)
• Outlaw Territory Volume 3: "Heaven Sent" (script and art, with Alex Sheikman, anthology, Image, 2013)
• Ghost vol. 3 #1-2 (with Kelly Sue DeConnick, Chris Sebela and Drew Edward Johnson (#2), Dark Horse, 2013–2014)
• Peanuts: A Tribute to Charles M. Schulz: "Charlie Brown and Snoopy" (script and art, anthology, KaBOOM!, 2015)
• Batman Beyond: Rebirth: "Escaping the Grave, Part 1" (with Dan Jurgens, one-shot, DC Comics, 2016)
• Superman vol. 4 #15: "Multiplicity, Part 2" (with Peter Tomasi, among other artists, DC Comics, 2017)
• Inhumans Prime (with Al Ewing and Chris Allen, one-shot, Marvel, 2017)
• The Flash vol. 5 #25 (with Joshua Williamson, Carmine Di Giandomenico and Neil Googe, DC Comics, 2017)
• The Kamandi Challenge #12: "The Boundless Realm" (with Gail Simone and Jill Thompson, DC Comics, 2017)
• The Man of Steel vol. 2 #3 (with Brian Michael Bendis and Jason Fabok, DC Comics, 2018)
• The Unexpected vol. 2 #1: "Call of the Unknown, Part 1 – Punch First" (with Steve Orlando and Cary Nord, DC Comics, 2018)
• From Hell's Heart: "The Confidence-Man" (with Herman Melville and John Arcudi, anthology graphic novel, A Wave Blue World, 2019)
• Legion of Super-Heroes (with Brian Michael Bendis, DC Comics):
  • Millennium #2 (with Jim Cheung, Nicola Scott and Jeff Dekal, 2019)
  • Legion of Super-Heroes vol. 7 #1-ongoing (2020–...)

Covers only

Dungeons & Dragons

• Races of Eberron (2005)
• Five Nations (2005)
• An Adventurer's Guide to Eberron (2008)

• Ryan Sook at the Grand Comics Database

• Official website
• Ryan Sook at the Comic Book DB (archived from the original)
• Arrant, Chris (November 14, 2008). "Covering it All: Chatting with Ryan Sook". Newsarama.com.
• "Ryan Sook :: Pen & Paper RPG Database". Archived from the original on May 19, 2007.