S1PR5
Identifiers
AliasesS1PR5, EDG8, Edg-8, S1P5, SPPR-1, SPPR-2, sphingosine-1-phosphate receptor 5
External IDsOMIM: 605146 MGI: 2150641 HomoloGene: 11031 GeneCards: S1PR5
Orthologs
SpeciesHumanMouse
Entrez

53637

94226

Ensembl

ENSG00000180739

ENSMUSG00000045087

UniProt

Q9H228

Q91X56

RefSeq (mRNA)

NM_030760
NM_001166215

NM_053190

RefSeq (protein)

NP_001159687
NP_110387

NP_444420

Location (UCSC)Chr 19: 10.51 – 10.52 MbChr 9: 21.15 – 21.16 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Sphingosine-1-phosphate receptor 5 also known as S1PR5 is a human gene which encodes a G protein-coupled receptor which binds the lipid signaling molecule sphingosine 1-phosphate (S1P). Hence this receptor is also known as S1P5.[5]

Agonists

Evolution

Paralogues for S1PR5 Gene

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000180739 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000045087 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: S1PR5 Sphingosine-1-phosphate receptor 5".
  6. ^ Hobson AD, Harris CM, van der Kam EL, Turner SC, Abibi A, Aguirre AL, Bousquet P, Kebede T, Konopacki DB, Gintant G, Kim Y, Larson K, Maull JW, Moore NS, Shi D, Shrestha A, Tang X, Zhang P, Sarris KK (Nov 2015). "Discovery of A-971432, An Orally Bioavailable Selective Sphingosine-1-Phosphate Receptor 5 (S1P5) Agonist for the Potential Treatment of Neurodegenerative Disorders". Journal of Medicinal Chemistry. 58 (23): 9154–70. doi:10.1021/acs.jmedchem.5b00928. PMID 26509640.
  7. ^ Roberts E, Guerrero M, Urbano M, Rosen H (Jul 2013). "Sphingosine 1-phosphate receptor agonists: a patent review (2010-2012)". Expert Opin Ther Pat. 23 (7): 817–41. doi:10.1517/13543776.2013.783022. PMID 23541049. S2CID 24421259.
  8. ^ "GeneCards®: The Human Gene Database".

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Cell surface receptor: G protein-coupled receptors
Categories