Protein-coding gene in the species Homo sapiens
SART3 |
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Identifiers |
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Aliases | SART3, DSAP1, P100, RP11-13G14, TIP110, p110, p110(nrb), squamous cell carcinoma antigen recognized by T-cells 3, squamous cell carcinoma antigen recognized by T cells 3, spliceosome associated factor 3, U4/U6 recycling protein |
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External IDs | OMIM: 611684 MGI: 1858230 HomoloGene: 40977 GeneCards: SART3 |
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Wikidata |
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Squamous cell carcinoma antigen recognized by T-cells 3 is a protein that in humans is encoded by the SART3 gene.[5][6][7]
The protein encoded by this gene is an RNA-binding nuclear protein that is a tumor-rejection antigen. This antigen possesses tumor epitopes capable of inducing HLA-A24-restricted and tumor-specific cytotoxic T lymphocytes in cancer patients and may be useful for specific immunotherapy. This gene product is found to be an important cellular factor for HIV-1 gene expression and viral replication. It also associates transiently with U6 and U4/U6 snRNPs during the recycling phase of the spliceosome cycle. This encoded protein is thought to be involved in the regulation of mRNA splicing.[7]
Interactions
SART3 has been shown to interact with RNPS1[8] and Androgen receptor.[9]