SCHEMBL5334361
Identifiers
  • 7-[(3-methoxyphenoxy)methyl]-2,3,4,5-tetrahydro-1H-3-benzazepine
CAS Number
PubChem CID
Chemical and physical data
FormulaC18H21NO2
Molar mass283.371 g·mol−1
3D model (JSmol)
  • COC1=CC(=CC=C1)OCC2=CC3=C(CCNCC3)C=C2
  • InChI=1S/C18H21NO2/c1-20-17-3-2-4-18(12-17)21-13-14-5-6-15-7-9-19-10-8-16(15)11-14/h2-6,11-12,19H,7-10,13H2,1H3
  • Key:BFCIUKMUJQOSDE-UHFFFAOYSA-N

SCHEMBL5334361 is a drug which acts as an agonist at the 5-HT2 family of serotonin receptors, and was developed for the treatment of glaucoma. It is a benzazepine derivative structurally related to the anorectic drug lorcaserin. It is selective for 5-HT2A, with an EC50 of 0.4nM at 5-HT2A vs 3.9nM at 5-HT2C and a much lower affinity of 417nM at 5-HT2B.[1]

See also

References

  1. ^ WO 2007149728, Mohapatra S, Hellberg MR, Feng Z, "Aryl and heteroaryl tetrahydrobenzazepine derivatives and their use for treating glaucoma", assigned to Alcon Manufacturing, Ltd.