SERPINE2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4DY0, 4DY7
Identifiers
Aliases	SERPINE2, GDN, GDNPF, PI-7, PI7, PN-1, PN1, PNI, serpin family E member 2
External IDs	OMIM: 177010 MGI: 101780 HomoloGene: 21247 GeneCards: SERPINE2
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q36.1 Start 223,975,045 bp[1] End 224,039,318 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 C4|1 40.97 cM Start 79,771,914 bp[2] End 79,838,897 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in stromal cell of endometrium ventral tegmental area tibia spinal ganglia external globus pallidus trigeminal ganglion superior vestibular nucleus frontal pole olfactory bulb subthalamic nucleus Top expressed in seminal vesicula calvaria cumulus cell olfactory epithelium body of femur ventral tegmental area ciliary body globus pallidus utricle ankle joint More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding glycosaminoglycan binding peptidase inhibitor activity heparin binding serine-type endopeptidase inhibitor activity signaling receptor binding Cellular component extracellular vesicle extrinsic component of external side of plasma membrane platelet alpha granule extracellular matrix cytosol neuromuscular junction extracellular region extracellular space collagen-containing extracellular matrix Biological process negative regulation of phosphatidylinositol 3-kinase signaling negative regulation of cell growth seminal vesicle epithelium development secretory granule organization innervation mating plug formation nervous system development detection of mechanical stimulus involved in sensory perception multicellular organism development regulation of cell migration long-term potentiation regulation of timing of cell differentiation cell differentiation negative regulation of proteolysis negative regulation of protein catabolic process negative regulation of plasminogen activation cerebellar granular layer morphogenesis negative regulation of cell population proliferation secretion by cell negative regulation of sodium ion transport negative regulation of smoothened signaling pathway negative regulation of protein processing positive regulation of astrocyte differentiation negative regulation of platelet activation response to wounding regulation of synaptic transmission, glutamatergic negative regulation of peptidase activity negative regulation of blood coagulation blood coagulation negative regulation of platelet aggregation negative regulation of endopeptidase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5270 20720 Ensembl ENSG00000135919 ENSMUSG00000026249 UniProt P07093 Q07235 RefSeq (mRNA) NM_001136528 NM_001136530 NM_006216 NM_009255 RefSeq (protein) NP_001130000 NP_001130002 NP_006207 NP_033281 Location (UCSC) Chr 2: 223.98 – 224.04 Mb Chr 1: 79.77 – 79.84 Mb PubMed search [3] [4]
Wikidata
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Glia-derived nexin is a protein that in humans is encoded by the SERPINE2 gene.^[5][6]