Small glutamine-rich tetratricopeptide repeat-containing protein alpha is a protein that in humans is encoded by the SGTA gene.^[1][2][3] SGTA orthologs^[4] have also been identified in several mammals for which complete genome data are available. STGA belongs to a family of co-chaperone proteins that obtain a TPR motif.^[5] STGA was discovered just 15 years ago.

SGTA
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2VYI, 4CPG, 4GOD, 4GOE, 4GOF
Identifiers
Aliases	SGTA, SGT, alphaSGT, hSGT, small glutamine rich tetratricopeptide repeat containing alpha, small glutamine rich tetratricopeptide repeat co-chaperone alpha, SGT1, Vpu
External IDs	OMIM: 603419 MGI: 1098703 HomoloGene: 31122 GeneCards: SGTA
Gene location (Human) Chr. Chromosome 19 (human)[6] Band 19p13.3 Start 2,754,715 bp[6] End 2,783,362 bp[6]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[7] Band 10 C1|10 39.72 cM Start 80,879,909 bp[7] End 80,896,015 bp[7]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gastrocnemius muscle middle frontal gyrus cingulate gyrus anterior pituitary amygdala left ventricle frontal pole nucleus accumbens putamen prefrontal cortex Top expressed in entorhinal cortex yolk sac lip superior frontal gyrus neural tube brown adipose tissue right ventricle internal carotid artery ankle external carotid artery More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding BAT3 complex binding protein self-association identical protein binding molecular adaptor activity Cellular component cytosol membrane nucleus cytoplasm presynapse extrinsic component of synaptic vesicle membrane TRC complex Biological process positive regulation of ER-associated ubiquitin-dependent protein catabolic process viral process ubiquitin-dependent ERAD pathway negative regulation of ER-associated ubiquitin-dependent protein catabolic process negative regulation of ubiquitin-dependent protein catabolic process tail-anchored membrane protein insertion into ER membrane chaperone-mediated protein folding posttranslational protein targeting to endoplasmic reticulum membrane positive regulation of chaperone-mediated protein folding Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6449 52551 Ensembl ENSG00000104969 ENSMUSG00000004937 UniProt O43765 Q8BJU0 RefSeq (mRNA) NM_003021 NM_024499 NM_001358549 NM_001358550 RefSeq (protein) NP_003012 NP_078775 NP_001345478 NP_001345479 Location (UCSC) Chr 19: 2.75 – 2.78 Mb Chr 10: 80.88 – 80.9 Mb PubMed search [8] [9]
Wikidata
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Function

The molecular function of the protein states that SGTA is a small glutamine-rich tetratricopeptide repeat (TRP)-containing protein, ubiquitously expressed, interacting with the NS1 protein of parvovirus H-1.^[10]

The SGTA gene encodes a protein that is capable of interacting with the major nonstructural protein of parvovirus H-1 and 70-kDa heat shock cognate protein; however, its function is not known. Since this transcript is expressed ubiquitously in various tissues, this protein may serve a housekeeping function.^[3]

Overview of main functions:^[5]

• hormone signaling
• viral assembly and release
• cell cycle and apoptosis
• intracellular compartmentalization
• neuronal synaptic transmission
• post-translational transport and modification of proteins.

Small glutamine-rich tetratricopeptide repeat-containing protein alpha (STGA) acts as a co-chaperone and regulator of androgen and growth hormone receptor signaling.^[5] The protein also mediates targets to the endoplasmic reticulum

Interactions

SGTA has been shown to interact with Growth hormone receptor.^[2]

Interacting Proteins for the SGTA Gene:^[10]

• HSPA4
• BAG6
• UBL4A
• HSPA8
• GET4

Associated Diseases

• Prostate, ovary, liver, and esophagus cancer
• Hormone-related polycystic ovary syndrome
• Amyloid-related Alzheimer's
• Prion Diseases