The family of non-collagenous proteins known as SIBLING proteins, standing for small integrin-binding ligand, N-linked glycoprotein, are components of the extracellular matrix of bone and dentin. Evidence shows that these proteins play key roles in the mineralization of these tissues.[1]
The following are categorized as SIBLING proteins:[1][2]
The genes coding for members of the SIBLING protein family are similarly organized and are all located on human chromosome 4q21-23.[3]