SIRPG
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 2JJW, 4I2X
Identifiers
Aliases	SIRPG, CD172g, SIRP-B2, SIRPB2, SIRPgamma, bA77C3.1, signal regulatory protein gamma
External IDs	OMIM: 605466 HomoloGene: 56809 GeneCards: SIRPG
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20p13 Start 1,629,152 bp[1] End 1,657,779 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in lymph node blood appendix spleen thymus rectum bone marrow cells gallbladder pharynx thymus n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component integral component of membrane plasma membrane membrane intracellular anatomical structure Biological process cell-cell signaling cell adhesion intracellular signal transduction positive regulation of T cell activation leukocyte migration positive regulation of cell population proliferation negative regulation of cell population proliferation positive regulation of cell-cell adhesion positive regulation of phagocytosis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55423 n/a Ensembl ENSG00000089012 n/a UniProt Q9P1W8 n/a RefSeq (mRNA) NM_001039508 NM_018556 NM_080816 n/a RefSeq (protein) NP_001034597 NP_061026 NP_543006 n/a Location (UCSC) Chr 20: 1.63 – 1.66 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

Signal-regulatory protein gamma is a protein that in humans is encoded by the SIRPG gene.^[3][4][5] SIRPG has also recently been designated CD172G (cluster of differentiation 172G).

The protein encoded by this gene is a member of the signal-regulatory protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. Alternatively spliced transcript variants encoding different isoforms have been described.^[5]