SIX2
Identifiers
Aliases	SIX2, SIX homeobox 2
External IDs	OMIM: 604994 MGI: 102778 HomoloGene: 56518 GeneCards: SIX2
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p21 Start 45,005,182 bp[1] End 45,009,452 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17 E4|17 55.72 cM Start 85,991,705 bp[2] End 85,995,702 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gastrocnemius muscle parotid gland tibialis anterior muscle palpebral conjunctiva pituitary gland periodontal fiber islet of Langerhans Achilles tendon anterior pituitary deltoid muscle Top expressed in maxillary prominence parotid gland external carotid artery internal carotid artery urethra utricle molar saccule male urethra conjunctival fornix More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding sequence-specific DNA binding DNA-binding transcription factor activity DNA-binding transcription activator activity, RNA polymerase II-specific transcription factor binding RNA polymerase II cis-regulatory region sequence-specific DNA binding protein-containing complex binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription cis-regulatory region binding Cellular component nucleus transcription regulator complex Biological process embryonic skeletal system morphogenesis regulation of chondrocyte differentiation regulation of transcription, DNA-templated positive regulation of chondrocyte proliferation chondrocyte differentiation protein import into nucleus kidney development negative regulation of cell differentiation anatomical structure morphogenesis mesenchymal stem cell maintenance involved in nephron morphogenesis mesenchymal to epithelial transition involved in metanephros morphogenesis mesenchymal cell differentiation involved in kidney development mesenchymal stem cell proliferation transcription by RNA polymerase II regulation of branching involved in ureteric bud morphogenesis multicellular organism development nephron morphogenesis nephron development middle ear morphogenesis embryonic digestive tract morphogenesis embryonic cranial skeleton morphogenesis regulation of ossification cell population proliferation mesodermal cell fate specification anterior/posterior axis specification metanephros development cell migration positive regulation of transcription by RNA polymerase II condensed mesenchymal cell proliferation negative regulation of transcription, DNA-templated anatomical structure development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10736 20472 Ensembl ENSG00000170577 ENSMUSG00000024134 UniProt Q9NPC8 Q8TBA2 Q62232 RefSeq (mRNA) NM_016932 NM_011380 RefSeq (protein) NP_058628 NP_058628.3 NP_035510 Location (UCSC) Chr 2: 45.01 – 45.01 Mb Chr 17: 85.99 – 86 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Homeobox protein SIX2 is a protein that in humans is encoded by the SIX2 gene.^[5][6]